Biomembrane Lab, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 6200 24, India.
Biomembrane Lab, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 6200 24, India.
Biomed Pharmacother. 2017 Nov;95:394-401. doi: 10.1016/j.biopha.2017.08.075. Epub 2017 Sep 12.
Hyperlipidemia in the male albino Wistar rats was induced by Triton WR - 1339. The treatment of the hyperlipidemic animals with the ethanol extract of Cassia auriculata flower (Et-CAF) exhibited a dose dependent reduction in serum triacylglycerol, total cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL) similar to the hyperlipidemic animals treated with standard drug atorvastatin. Hyperlipidemia altered the protein and mRNA expression levels of the key genes (SREBP-1c, ACC1, SREBP-2, HMGR, HMGS, CYP7A1, and ABCA1) in lipid metabolism and the treatment with Et-CAF (300mg/kg b. wt) reverted these levels similar to that observed with atorvastatin treated hyperlipidemic animals. These results revealed that Et-CAF extract served as an efficient anti-hyperlipidemic drug.
雄性白化 Wistar 大鼠的高脂血症是由 Triton WR - 1339 诱导的。用 Cassia auriculata 花的乙醇提取物（Et-CAF）治疗高脂血症动物，可使血清三酰甘油、总胆固醇、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）呈剂量依赖性降低，类似于用标准药物阿托伐他汀治疗的高脂血症动物。高脂血症改变了脂质代谢关键基因（SREBP-1c、ACC1、SREBP-2、HMGR、HMGS、CYP7A1 和 ABCA1）的蛋白和 mRNA 表达水平，而 Et-CAF（300mg/kg b.wt）治疗可使这些水平恢复正常，类似于用阿托伐他汀治疗的高脂血症动物。这些结果表明，Et-CAF 提取物是一种有效的抗高脂血症药物。
