Placental Analytics, LLC, New Rochelle, NY, USA.
Institute for Basic Research, Staten Island, NY, USA.
Placenta. 2017 Sep;57:9-12. doi: 10.1016/j.placenta.2017.05.017. Epub 2017 May 28.
The umbilical cord is the crucial pathway for blood flow between the fetus and the placenta. Umbilical coiling and length have been separately linked to adverse clinical outcomes; however, the effects of variations of these parameters on umbilical arterial blood flow are not well understood. Using 3D computational model, we studied the individual and combined effects of umbilical coiling index, cord length and arterial diameter on umbilical artery hemodynamics. We found that specific combinations of umbilical coiling index, cord length and arterial diameter yielded pressure and flow drops incompatible with fetal life. Such models are useful as hypothesis-developing tools.
脐带是胎儿和胎盘之间血液流动的关键途径。脐带缠绕和长度分别与不良临床结局相关；然而，这些参数变化对脐动脉血流的影响尚不清楚。本研究采用三维计算模型，研究了脐带缠绕指数、脐带长度和动脉直径对脐动脉血液动力学的单独和联合影响。我们发现，特定的脐带缠绕指数、脐带长度和动脉直径组合会导致压力和流量下降，这与胎儿的生命不相容。这些模型可用作假设开发工具。
