Department of Microbiology & Cell Biology, Indian Institute of Science, Bangalore, India.
Department of Microbiology & Cell Biology, Indian Institute of Science, Bangalore, India.
Infect Genet Evol. 2017 Nov;55:228-235. doi: 10.1016/j.meegid.2017.08.030. Epub 2017 Aug 31.
Hand foot and mouth disease (HFMD) is a relatively unreported disease in India. This study was undertaken to characterize the enterovirus type/s associated with two unexpectedly-massive epidemics that occurred in Bangalore, India in 2013 and 2015. Stool samples of 229 children with HFMD living in Northern and Southern areas of Bangalore were tested by RT-PCR; 189 (82.5%) were enterovirus positive. The Indian CV-A16 strains exhibited 98-99% sequence identity with those reported in France and China in the 5' untranslated region. BLAST and phylogenetic analyses of complete genomes of representative Indian isolates revealed that the 2015 epidemic was predominated by an inter-species recombinant between CV-A16 and coxsackievirus B5. The 2013 epidemic was primarily caused by nonrecombinant strains. The CV-A16 strains circulated in India since 2007 and phylogeographic analyses indicated imported cases in France and China. In conclusion, CV-A16-associated HFMD epidemics should be recognized as an emerging public health problem in India.
手足口病（HFMD）在印度的报道相对较少。本研究旨在对 2013 年和 2015 年在印度班加罗尔发生的两起异常大规模疫情中与手足口病相关的肠病毒进行鉴定。通过 RT-PCR 检测了来自班加罗尔北部和南部地区的 229 例手足口病患儿的粪便样本，其中 189 例（82.5%）为肠病毒阳性。印度的 CV-A16 株在 5'非翻译区与法国和中国报告的 CV-A16 株具有 98-99%的序列同一性。代表性印度分离株全基因组的 BLAST 和系统发育分析表明，2015 年的疫情主要由 CV-A16 和柯萨奇病毒 B5 之间的种间重组引起。2013 年的疫情主要由非重组株引起。自 2007 年以来，印度就有 CV-A16 株流行，系统地理分析表明法国和中国有输入病例。综上所述，CV-A16 相关的手足口病疫情应被视为印度的一个新出现的公共卫生问题。
