Preskorn S H, Goodwin D W
Int J Psychiatry Med. 1987;17(2):117-31. doi: 10.2190/q1y8-8858-gnpp-8reh.
Since the advent of modern psychopharmacology in the 1950s, use of medications in the treatment of many psychiatric disorders has become commonplace. Alcohol use is also widespread. As alcohol can interact with a wide variety of medications to alter drug effects, understanding the interactions between it and psychiatric medicines is important to the efficacious treatment of the depressed alcoholic with these drugs. This article briefly outlines the effects of alcohol and the mechanisms of its interactions with psychiatric medications. The most commonly used classes of psychiatric medicines, including antidepressants, CNS depressants, benzodiazepines, antipsychotics, psychostimulants, and lithium carbonate, are reviewed as to their potential interactions with alcohol. Clinical implications of these interactions are discussed.
自20世纪50年代现代精神药理学问世以来，使用药物治疗多种精神疾病已变得很普遍。酒精的使用也很广泛。由于酒精可与多种药物相互作用以改变药物效果，了解酒精与精神科药物之间的相互作用对于使用这些药物有效治疗抑郁的酗酒者很重要。本文简要概述了酒精的作用及其与精神科药物相互作用的机制。对最常用的几类精神科药物，包括抗抑郁药、中枢神经系统抑制剂、苯二氮䓬类药物、抗精神病药、精神兴奋剂和碳酸锂，就它们与酒精的潜在相互作用进行了综述。讨论了这些相互作用的临床意义。
