肌动蛋白丝的德雷布林A重塑及其意义

Remodeling of Actin Filaments by Drebrin A and Its Implications.

作者信息

Grintsevich Elena E

机构信息

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

出版信息

Adv Exp Med Biol. 2017;1006:61-82. doi: 10.1007/978-4-431-56550-5_5.

DOI:10.1007/978-4-431-56550-5_5

PMID:28865015

Abstract

Dendritic spines are small protrusions of dendrites that are critical for synaptic transmission. The plasticity and stability of dendritic spines is tightly linked to actin cytoskeleton. However, our understanding of specific properties and the fine-tuning of neuronal actin structures is incomplete. Drebrin A is highly enriched in dendritic spines, but its effects on actin morphology, dynamics, and interplay with other actin regulators are yet to be clarified. Here we review recent advances in understanding drebrin effects on actin morphology and dynamics.

摘要

树突棘是树突的小突起，对突触传递至关重要。树突棘的可塑性和稳定性与肌动蛋白细胞骨架紧密相连。然而，我们对神经元肌动蛋白结构的特定特性和精细调节的理解并不完整。Drebrin A在树突棘中高度富集，但其对肌动蛋白形态、动力学以及与其他肌动蛋白调节因子相互作用的影响尚待阐明。在此，我们综述了在理解Drebrin对肌动蛋白形态和动力学影响方面的最新进展。