Naro Antonino, Bramanti Placido, Bramanti Alessia, Calabrò Rocco Salvatore
IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Conscious Cogn. 2017 Oct;55:148-155. doi: 10.1016/j.concog.2017.08.009. Epub 2017 Aug 30.
The deterioration of sensory-motor integration within the pain matrix in patients with chronic Disorders of Consciousness (DoC) is one of the principal mechanisms responsible for non-conscious pain perception. The present study aimed to assess whether the variability in the inter-peak interval (IPI) between the N2 and P2 components of laser evoked potentials (LEP) could represent an objective marker of the behavioral responsiveness to nociceptive stimulation, as measured by the Nociception Coma Scale-Revised (NCS-R), and regardless of the sensory part of pain processing. We found that only IPI variability showed a significant correlation with NCS-R score, independently of the stimulation intensity (that influences the sensory part of pain processing). It was thus concluded that IPI variability might represent an objective measure of pain processing, which may help clinicians in the development of effective pain management strategies.
慢性意识障碍（DoC）患者疼痛矩阵内感觉运动整合功能的恶化是导致无意识疼痛感知的主要机制之一。本研究旨在评估激光诱发电位（LEP）的N2和P2成分之间的峰间间隔（IPI）变化是否可作为行为对伤害性刺激反应性的客观指标，该反应性通过修订的伤害性昏迷量表（NCS-R）进行测量，且与疼痛处理的感觉部分无关。我们发现，仅IPI变化与NCS-R评分存在显著相关性，且与刺激强度无关（刺激强度会影响疼痛处理的感觉部分）。因此得出结论，IPI变化可能代表疼痛处理的客观指标，这可能有助于临床医生制定有效的疼痛管理策略。
