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糖尿病足溃疡及伴发疾病患者大肢体截肢风险的Meta分析。

Risk of major limb amputation in diabetic foot ulcer and accompanying disease: A meta-analysis.

作者信息

Shin Jin Yong, Roh Si-Gyun, Sharaf Basel, Lee Nae-Ho

机构信息

Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University, Jeonju, Republic of Korea; Research Institute of Clinical Medicine-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.

Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University, Jeonju, Republic of Korea; Research Institute of Clinical Medicine-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea; Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.

出版信息

J Plast Reconstr Aesthet Surg. 2017 Dec;70(12):1681-1688. doi: 10.1016/j.bjps.2017.07.015. Epub 2017 Aug 5.

DOI:10.1016/j.bjps.2017.07.015
PMID:28865989
Abstract

BACKGROUND

Limb amputation in diabetic patients raises important issues regarding low quality of life and survival rates. This meta-analysis aimed to identify predictive factors accompanying diseases with high major amputation rates in diabetic patients.

METHODS

A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE and Cochrane databases. Eight variables were extracted from the included studies and evaluated according to major amputation rates. The Newcastle-Ottawa scale (NOS) was utilized to assess the quality of the studies.

RESULTS

The search strategy identified 101 publications. After screening, 10 articles were selected for review. Hypertension, ischemic heart disease, cerebrovascular disease, and peripheral vascular disease were identified as predictive variables of higher major amputation rates.

CONCLUSIONS

Although further investigation of long-term and prospective studies is needed, we identified four variables as predisposing factors for higher major amputation in diabetic patients through meta-analysis.

摘要

背景

糖尿病患者的肢体截肢引发了关于生活质量低下和生存率的重要问题。本荟萃分析旨在确定糖尿病患者中伴随高主要截肢率疾病的预测因素。

方法

使用MEDLINE、EMBASE和Cochrane数据库进行系统的文献综述和荟萃分析。从纳入的研究中提取八个变量，并根据主要截肢率进行评估。采用纽卡斯尔-渥太华量表（NOS）评估研究质量。

结果

检索策略共识别出101篇出版物。筛选后，选择10篇文章进行综述。高血压、缺血性心脏病、脑血管疾病和外周血管疾病被确定为较高主要截肢率的预测变量。

结论

尽管需要对长期和前瞻性研究进行进一步调查，但我们通过荟萃分析确定了四个变量为糖尿病患者较高主要截肢的易感因素。

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