Hinohara Y, Yamazaki T, Kuromaru O, Homma N, Sakai K
J Pharm Pharmacol. 1987 Jul;39(7):512-6. doi: 10.1111/j.2042-7158.1987.tb03168.x.
The effects of equihypotensive doses of nicorandil and verapamil on plasma digoxin concentrations have been assessed in rats and dogs. In a single digoxin dose study, digoxin (1 mg kg-1) alone, or in combination with nicorandil (5 mg kg-1) or verapamil (25 mg kg-1) was given orally to rats. When given chronically to rats, a single dose of digoxin (1 mg kg-1) orally for 7 consecutive days was followed, on day 8, by digoxin alone, or together with nicorandil (5 mg kg-1) or verapamil (25 mg kg-1). In dogs, a loading dose of digoxin (50 micrograms kg-1) was given orally on day 1, then 25 micrograms kg-1 was administered for the following 6 days. On day 8, digoxin (50 micrograms kg-1) was given with nicorandil (5 mg kg-1) or verapamil (20 mg kg-1). In rats, the AUC0-24 and Cmax of plasma digoxin were enhanced significantly by coadministration of verapamil, but not by nicorandil. In dogs, verapamil significantly increased the Cmax of plasma digoxin, but not the AUC. Nicorandil had no effect on either parameter.
已在大鼠和犬中评估了等降压剂量的尼可地尔和维拉帕米对血浆地高辛浓度的影响。在一项单次地高辛剂量研究中，单独给大鼠口服地高辛（1 mg/kg），或与尼可地尔（5 mg/kg）或维拉帕米（25 mg/kg）联合给药。当对大鼠长期给药时，连续7天每天口服单剂量地高辛（1 mg/kg），在第8天，单独给予地高辛，或与尼可地尔（5 mg/kg）或维拉帕米（25 mg/kg）一起给药。在犬中，第1天口服地高辛负荷剂量（50 μg/kg），随后6天每天给予25 μg/kg。在第8天，给予地高辛（50 μg/kg）与尼可地尔（5 mg/kg）或维拉帕米（20 mg/kg）。在大鼠中，维拉帕米联合给药显著提高了血浆地高辛的AUC0-24和Cmax，但尼可地尔没有。在犬中，维拉帕米显著增加了血浆地高辛的Cmax，但没有增加AUC。尼可地尔对这两个参数均无影响。
