Zwierzyńska Ewa, Krupa-Burtnik Agata, Pietrzak Bogusława
Department of Pharmacodynamics, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland.
Department of Pharmacodynamics, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland.
Epilepsy Behav. 2017 Oct;75:170-175. doi: 10.1016/j.yebeh.2017.08.004. Epub 2017 Sep 1.
Retigabine is a novel antiepileptic drug with a unique and complex mechanism of action which allows its use in many diseases associated with impaired neuronal activity. This study sought to examine the impact of retigabine on two types of memory in rats.
Adult male Wistar rats were used to assess the effect of retigabine, administered p.o. as single (10mg/kg or 20mg/kg) or repeated doses, on spatial memory with the Morris water maze test (MWM) and emotional memory, associated with fear, with the passive avoidance test (PA).
Retigabine administered at a high single dose transiently impairs learning processes in rats. In the MWM, these changes were delayed in time and of a lesser degree when retigabine was given at low single dose. Additionally, the drug administered repeatedly for 2weeks slowed learning processes in the MWM, but this effect occurred only after 1week of administration in the PA.
These findings indicate that retigabine may affect memory and learning processes, especially in the first phase of administration.
瑞替加滨是一种新型抗癫痫药物，其作用机制独特且复杂，可用于治疗多种与神经元活动受损相关的疾病。本研究旨在探讨瑞替加滨对大鼠两种记忆类型的影响。
成年雄性Wistar大鼠用于评估口服给予瑞替加滨单次剂量（10mg/kg或20mg/kg）或重复剂量后，通过莫里斯水迷宫试验（MWM）对空间记忆以及通过被动回避试验（PA）对与恐惧相关的情绪记忆的影响。
高单次剂量给予瑞替加滨会短暂损害大鼠的学习过程。在MWM中，当给予低单次剂量瑞替加滨时，这些变化在时间上延迟且程度较小。此外，连续2周重复给药该药物会减缓MWM中的学习过程，但这种效应仅在PA给药1周后出现。
这些发现表明瑞替加滨可能会影响记忆和学习过程，尤其是在给药的第一阶段。
