调控多能干细胞中的内源性逆转录病毒及其重编程。

Regulation of ERVs in pluripotent stem cells and reprogramming.

机构信息

Epigenetics and Cell Fates Laboratory, Programme in Stem Cell, Regenerative Medicine and Ageing, A*STAR Institute of Molecular and Cell Biology, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.

出版信息

Curr Opin Genet Dev. 2017 Oct;46:194-201. doi: 10.1016/j.gde.2017.07.012. Epub 2017 Sep 1.

DOI:10.1016/j.gde.2017.07.012

PMID:28866476

Abstract

Recent advances in our understanding of endogenous retroviruses (ERVs) regulation and its functional aspects have provided us with vast power to unravel its role in the host's genome. Co-evolutionary model of ERVs and Kruppel associated box-Zinc Finger Proteins (KRAB-ZFPs) provides a deeper knowledge of how the genome is shaped during the course of evolution. However, the role of ERVs in normal cellular function still remains an enigma. Here we review studies in recent years with a focus on the role of ERVs in maintaining stemness and cell fate reprogramming, along with the recent discoveries of novel regulatory factors which have been shown to mediate ERV expression in both canonical and non-canonical pathways.

摘要

近年来，我们对内源性逆转录病毒 (ERVs) 调控及其功能方面的认识取得了进展，这为我们提供了深入了解其在宿主基因组中作用的强大能力。ERVs 和 Kruppel 相关盒锌指蛋白 (KRAB-ZFPs) 的共同进化模型提供了更深入的知识，了解了基因组在进化过程中是如何形成的。然而，ERVs 在正常细胞功能中的作用仍然是一个谜。在这里，我们回顾了近年来的研究，重点关注 ERVs 在维持干细胞特性和细胞命运重编程中的作用，以及最近发现的新型调节因子，这些因子已被证明可以在经典和非经典途径中调节 ERV 的表达。