Pinho Daniella F, Subramaniam Rathan M
Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA.
Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Clinical Sciences, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Department of Biomedical Engineering, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA; Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8896, USA.
PET Clin. 2017 Oct;12(4):407-421. doi: 10.1016/j.cpet.2017.05.003. Epub 2017 Jul 15.
F-FDG PET/CT has been described as an accurate tool for initial diagnosis of pancreatic adenocarcinoma. It differentiates benign from malignant causes; detects local and, especially, distant spread of disease; and is a very good predictor of patient prognosis. Pancreatic neuroendocrine tumors are rare tumors that originate from the islet cells of the pancreas. Currently, Ga-DOTA-labeled somatostatin analogs are considered the best modality for detection of well-differentiated neuroendocrine tumors. F-FDG PET/CT has a role in patients with poorly differentiated tumors. Recent studies have demonstrated improved survival in patients with metastatic neuroendocrine tumors treated with radiolabeled somatostatin analogs.
F-FDG PET/CT已被描述为胰腺腺癌初始诊断的一种准确工具。它能区分良性与恶性病因；检测疾病的局部，尤其是远处扩散；并且是患者预后的良好预测指标。胰神经内分泌肿瘤是起源于胰腺胰岛细胞的罕见肿瘤。目前，镓-多胺多羧基配合物标记的生长抑素类似物被认为是检测高分化神经内分泌肿瘤的最佳方式。F-FDG PET/CT在低分化肿瘤患者中发挥作用。最近的研究表明，接受放射性标记生长抑素类似物治疗的转移性神经内分泌肿瘤患者生存率有所提高。
