Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Trends Cell Biol. 2017 Oct;27(10):700-702. doi: 10.1016/j.tcb.2017.08.006. Epub 2017 Aug 31.
The carrier translocase (TIM22 complex) inserts hydrophobic proteins into the mitochondrial inner membrane. Recently, the acylglycerol kinase (AGK) mutated in Sengers syndrome was identified as a novel subunit of the human TIM22 complex. This finding reveals an exciting link between mitochondrial protein and lipid biogenesis.
载体转位酶（TIM22 复合物）将疏水性蛋白插入线粒体的内膜中。最近，在 Sengers 综合征中突变的酰基甘油激酶（AGK）被鉴定为人类 TIM22 复合物的一个新亚基。这一发现揭示了线粒体蛋白质和脂质生物发生之间令人兴奋的联系。
