Vlenterie Richelle, van Ras Hilde W P, Roeleveld Nel, Pop-Purceleanu Monica, van Gelder Marleen M H J
Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
J Psychosom Res. 2017 Oct;101:96-103. doi: 10.1016/j.jpsychores.2017.08.008. Epub 2017 Aug 5.
The Patient Health Questionnaire-2 (PHQ-2) is a commonly used 2-item screening tool for depressive symptoms among pregnant women in primary care settings. However, its validity has not been assessed for large-scale epidemiological studies. Therefore, the aim of this study was to provide an epidemiological evaluation of the PHQ-2 among pregnant women.
A total of 3033 pregnant women participating in the PRegnancy and Infant DEvelopment Study completed the PHQ-2 as well as the Hospital Anxiety Depression Scale-Depression (HADS-D) or the Edinburgh Depression Scale (EDS) three times throughout pregnancy. The validity of the PHQ-2 was assessed with the HADS-D/EDS as reference standard.
Sensitivity and specificity of the PHQ-2 were 69-84% and 79-84%, respectively. The positive predictive values (range 19-26%) were substantially lower than the negative predictive values (96-99%).
Despite the relatively high number of false-positive screens, initial screening for depression by two questions only may enhance routine evaluation of depressive symptoms among pregnant women.
患者健康问卷-2（PHQ-2）是基层医疗环境中用于筛查孕妇抑郁症状的常用两项筛查工具。然而，其在大规模流行病学研究中的有效性尚未得到评估。因此，本研究旨在对孕妇群体中的PHQ-2进行流行病学评估。
共有3033名参与妊娠与婴儿发育研究的孕妇在整个孕期三次完成了PHQ-2以及医院焦虑抑郁量表-抑郁分量表（HADS-D）或爱丁堡产后抑郁量表（EDS）。以HADS-D/EDS作为参考标准评估PHQ-2的有效性。
PHQ-2的敏感性和特异性分别为69 - 84%和79 - 84%。阳性预测值（范围为19 - 26%）显著低于阴性预测值（96 - 99%）。
尽管假阳性筛查数量相对较多，但仅通过两个问题进行抑郁初筛可能会加强对孕妇抑郁症状的常规评估。
