Broncel Adam, Bocian Renata, Kłos-Wojtczak Paulina, Konopacki Jan
Medical Technology Centre, Natolin 15, 92-701 Łódź, Poland.
Department of Neurobiology, Faculty of Biology and Environmental Protection, The University of Łódź, Pomorska Str. No 141/143, 90-236 Łódź, Poland.
Brain Res. 2017 Nov 15;1675:41-50. doi: 10.1016/j.brainres.2017.08.030. Epub 2017 Sep 1.
Vagus nerve stimulation (VNS) has been used for years to treat patients with drug-resistant epilepsy. In the present study, the effect of different stimulation protocols of VNS on the hippocampal formation (HPC) type II theta field potentials were evaluated in anesthetized rats. The following theta parameters were analysed: power, frequency and duration of theta epochs. We documented for the first time the presence of HPC type II theta in response to the application of VNS. A VNS-induced theta rhythm appeared in different experimental protocols and, depending on the current intensity, could occur directly during VNS (brief effect) or after vagal stimulation (delayed effect), using lower intensity stimuli.
迷走神经刺激（VNS）已被用于治疗耐药性癫痫患者多年。在本研究中，在麻醉大鼠中评估了VNS不同刺激方案对海马结构（HPC）II型θ场电位的影响。分析了以下θ参数：θ波的功率、频率和持续时间。我们首次记录到在应用VNS时出现了HPC II型θ波。在不同的实验方案中出现了VNS诱导的θ节律，并且根据电流强度的不同，使用较低强度刺激时，它可能在VNS期间直接出现（短暂效应）或在迷走神经刺激后出现（延迟效应）。
