Torabi Masoumeh, Pooriamehr Alireza, Bigdeli Imanollah, Miladi-Gorji Hossein
Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran.
Faculty of Educational Sciences and Psychology, Ferdowsi University of Mashhad, Mashhad, Iran.
Neurosci Lett. 2017 Oct 17;659:110-114. doi: 10.1016/j.neulet.2017.08.074. Epub 2017 Sep 1.
This study was designed to examine whether maternal swimming exercise during pregnancy would attenuate prenatally morphine-induced anxiety, depression and voluntary consumption of morphine in the pubertal male and female rat offspring. Pregnant rats during the development of morphine dependence were allowed to swim (30-45min/d, 3days per a week) on gestational days 11-18. Then, the pubertal male and female rat offspring were tested for the elevated plus-maze (EPM), sucrose preference test (SPT) and voluntary morphine consumption using a two-bottle choice (TBC) paradigm. The results showed that male and female rat offspring born of the swimmer morphine-dependent mothers exhibited an increase in EPM open arm time and entries, higher levels of sucrose preference than their sedentary control mothers. Voluntary consumption of morphine was less in the male and female rat offspring born of the swimmer morphine-dependent mothers as compared with their sedentary control mothers during three periods of the intake of drug. Thus, swimming exercise in pregnant morphine dependent mothers decreased anxiety, depressive-like behavior and also the voluntary morphine consumption in the pubertal male and female offspring, which may prevent prenatally morphine-induced behavioral sensitization in offspring.
本研究旨在探讨孕期母体游泳锻炼是否会减轻青春期雄性和雌性大鼠后代因产前接触吗啡而导致的焦虑、抑郁以及吗啡的自愿摄入量。在吗啡依赖形成期的怀孕大鼠，于妊娠第11至18天允许其游泳（30 - 45分钟/天，每周3天）。然后，对青春期雄性和雌性大鼠后代进行高架十字迷宫（EPM）测试、蔗糖偏好试验（SPT），并使用双瓶选择（TBC）范式测试其吗啡自愿摄入量。结果显示，游泳的吗啡依赖母体所生的雄性和雌性大鼠后代在EPM开放臂的停留时间和进入次数增加，蔗糖偏好水平高于久坐不动的对照母体所生后代。在药物摄入的三个阶段，游泳的吗啡依赖母体所生的雄性和雌性大鼠后代的吗啡自愿摄入量均低于久坐不动的对照母体所生后代。因此，怀孕的吗啡依赖母体进行游泳锻炼可降低青春期雄性和雌性后代的焦虑、类抑郁行为以及吗啡自愿摄入量，这可能会预防后代因产前接触吗啡而导致的行为敏感化。
