Simone Elena, Klapwijk Anneke R, Wilson Chick C, Nagy Zoltan K
School of Food Science and Nutrition, University of Leeds, Leeds, LS29JT, U.K.
Department of Chemical Engineering, Loughborough University, Loughborough LE113TU, U.K.
Cryst Growth Des. 2017 Apr 5;17(4):1695-1706. doi: 10.1021/acs.cgd.6b01683. Epub 2017 Mar 9.
Crystal size and shape can be manipulated to enhance the qualities of the final product. In this work the steady-state shape and size of succinic acid crystals, with and without a polymeric additive (Pluronic P123) at 350 mL, scale is reported. The effect of the amplitude of cycles as well as the heating/cooling rates is described, and convergent cycling (direct nucleation control) is compared to static cycling. The results show that the shape of succinic acid crystals changes from plate- to diamond-like after multiple cycling steps, and that the time required for this morphology change to occur is strongly related to the type of cycling. Addition of the polymer is shown to affect both the final shape of the crystals and the time needed to reach size and shape steady-state conditions. It is shown how this phenomenon can be used to improve the design of the crystallization step in order to achieve more efficient downstream operations and, in general, to help optimize the whole manufacturing process.
可以通过控制晶体的大小和形状来提高最终产品的质量。在这项工作中，报告了在350毫升规模下，有无聚合物添加剂（普朗尼克P123）时琥珀酸晶体的稳态形状和尺寸。描述了循环幅度以及加热/冷却速率的影响，并将收敛循环（直接成核控制）与静态循环进行了比较。结果表明，经过多个循环步骤后，琥珀酸晶体的形状从片状变为菱形，并且这种形态变化发生所需的时间与循环类型密切相关。结果表明，添加聚合物会影响晶体的最终形状以及达到尺寸和形状稳态条件所需的时间。展示了如何利用这一现象来改进结晶步骤的设计，以实现更高效的下游操作，并总体上有助于优化整个制造过程。
