Schlee Markus, Schad Till, Koch Jan H, Cattin Philippe C, Rathe Florian
32 Schöne Zähne, Forchheim, Germany.
Department of Maxillofacial Surgery, Goethe University, Frankfurt, Germany.
J Investig Clin Dent. 2018 Feb;9(1). doi: 10.1111/jicd.12286. Epub 2017 Sep 3.
The aim of the present study was to investigate the clinical performance of self-assembling peptide P -4 on non-cavitated initial proximal carious lesions 12 months after treatment.
Twenty-six patients, aged between 18 and 65 years, with 35 carious lesions were included in this practice-based, uncontrolled, prospective case series. The opacity and size of the proximal lesions were evaluated visually at baseline and at day 360 using standardized single-tooth or bite-wing and digital-subtraction radiography. Pairwise evaluation of images was carried out in a randomized and blinded manner with respect to the time point.
Twelve months after treatment of the proximal carious lesions, the visual evaluation showed a predominant shift toward regression of the initial lesions. Radiographic assessment yielded regression of the caries in 17 of 28 cases; four of 28 were regarded as unchanged, and seven of 28 lesions showed progression of the carious lesion. Combined assessment of clinical radiographs and digital subtraction radiographs confirmed the radiographic assessment, with 20 of 28 lesions showing total or partial regression, four unchanged, and four progressing.
Radiographic and digital subtraction analyses suggest that initial proximal carious lesions can regress after treatment with P -4, but additional factors might influence the overall treatment outcome.
本研究旨在调查自组装肽P -4治疗非空洞性早期邻面龋损12个月后的临床疗效。
本基于实践的、非对照的前瞻性病例系列纳入了26例年龄在18至65岁之间、患有35处龋损的患者。在基线和第360天时，使用标准化单牙片或咬合翼片及数字减影X线摄影对邻面龋损的透明度和大小进行视觉评估。图像的成对评估在随机且盲法的状态下针对时间点进行。
邻面龋损治疗12个月后，视觉评估显示初始龋损主要向消退方向转变。影像学评估显示28例中有17例龋损消退；28例中有4例被视为无变化，28例中有7例龋损病变进展。临床X线片和数字减影X线片的综合评估证实了影像学评估结果，28例中有20例显示完全或部分消退，4例无变化，4例进展。
影像学和数字减影分析表明，用P -4治疗后，初始邻面龋损可能会消退，但其他因素可能会影响总体治疗结果。
