[Not Available].

作者信息

Susperregui J, Pierry C, Bonhomme B, Pasticier G, Bernhard J-C, Capon G, Bensadoun H, Ballanger P, Ferrière J-M, Robert G

机构信息

Service d'urologie, centre hospitalier universitaire de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.

Service d'anatomopathologie, centre hospitalier universitaire de Bordeaux, France.

出版信息

Prog Urol. 2017 Oct;27(12):632-639. doi: 10.1016/j.purol.2017.07.239. Epub 2017 Aug 30.

DOI:10.1016/j.purol.2017.07.239

PMID:28869168

Abstract

OBJECTIVES

The aim of this study was to assess the impact of the aggressiveness of cancer cells at the level of positive surgical margins (PSM) on the biochemical recurrence rate (BRR) by studying the Gleason score (GS) at this level.

METHODS

We included all radical prostatectomy (RP) procedures performed from January 2007 to November 2011. All of the RP specimens with PSM were reviewed to determine the GS at the level of PSM. We compared the GS at PSM with BRR.

RESULTS

A total of 658 RP were analysed, among which 16% had PSM. From the 101 patients with PSM included, 32% had biochemical recurrence (BR) with a median follow-up of 38 months. GS at PSM was significantly associated with earlier BR (P=0.008). Univariate analysis showed that GS at PSM (P=0.013), initial PSA (P<0.0001), pathologic GS (P<0.001), length of PSM (P=0.013), and seminal vesicle invasion (P<0.0001) were predictors of BR. Multivariate analysis confirmed that PSA greater than 10ng/mL and length of PSM greater than 3mm were independent prognostic factors for BR, but GS at the level of PSM was not.

CONCLUSION

GS at PSM was not confirmed as an independent risk factor for BR. Initial PSA greater than 10ng/mL and length of PSM greater than 3mm were the sole independent predictors for BR.