Rudzińska-Szostak Ewa, Berlicki Łukasz
Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370, Wrocław, Poland.
Chemistry. 2017 Oct 26;23(60):14980-14986. doi: 10.1002/chem.201702730. Epub 2017 Oct 4.
Peptide foldamers have been studied for over two decades and numerous sequence patterns have been shown to form well-defined three-dimensional arrangements in solution. In particular, helices of various geometries have been described. In this article, different concepts concerning the construction of helical foldameric peptides, for which the possibility of governing the sense of the formed helix was evidenced, are presented and discussed.
肽折叠体已经被研究了二十多年，并且已经证明许多序列模式在溶液中能形成明确的三维排列。特别是，已经描述了各种几何形状的螺旋。在本文中，将介绍并讨论关于构建螺旋折叠肽的不同概念，对于这些概念，已经证明了控制所形成螺旋方向的可能性。
