Jia Lianzhi, Li Tingdong, Ge Shengxiang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infection Disease, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China.
Sheng Wu Gong Cheng Xue Bao. 2017 Jul 25;33(7):1075-1084. doi: 10.13345/j.cjb.160480.
Rotaviruses are leading causes of worldwide acute diarrhea in children younger than 5 years old, with severe consequence of social and economic burden. Vaccination is the most effective way to control rotavirus infection, however, the licensed rotavirus vaccines are ineffective in some low-income countries of Africa and Asia, where the mortality caused by rotavirus is higher than other areas. In addition, there are also safety concerns such as increased risk of intussusception. Therefore, it is urgent to improve the efficiency and safety of rotavirus vaccine to reduce the morbidity and mortality caused by rotavirus. Till now, many efforts are made to improve the effectiveness of rotavirus vaccines, and the inactive vaccine becomes the main trend in the research of rotavirus vaccine. The developments in recombinant rotavirus vaccines, especially in VP4 subunit vaccines are summarized in this review, and it could be helpful to develop effective recombinant rotavirus vaccines in further studies.
轮状病毒是全球5岁以下儿童急性腹泻的主要病因，会造成严重的社会和经济负担。接种疫苗是控制轮状病毒感染的最有效方法，然而，已获许可的轮状病毒疫苗在非洲和亚洲的一些低收入国家无效，这些国家由轮状病毒导致的死亡率高于其他地区。此外，还存在诸如肠套叠风险增加等安全问题。因此，迫切需要提高轮状病毒疫苗的效率和安全性，以降低轮状病毒引起的发病率和死亡率。到目前为止，人们为提高轮状病毒疫苗的有效性做出了许多努力，而灭活疫苗成为轮状病毒疫苗研究的主要趋势。本综述总结了重组轮状病毒疫苗的进展，特别是VP4亚单位疫苗的进展，这可能有助于在进一步研究中开发有效的重组轮状病毒疫苗。
