[Clinical efficacy of enhanced recovery after surgery in atrial caval shunting for type Ⅱ Budd-Chiari syndrome].

To investigate the clinical efficacy of enhanced recovery after surgery(ERAS) in atrial caval shunting (ACS) for type Ⅱ Budd-Chiari syndrome(BCS). The clinical data of patients underwent ACS for type Ⅱ BCS in the Henan Province People's Hospital from January 2014 to June 2016 were prospectively analyzed.Randomized and single-blind, controlled study was performed among the patients, and all of them underwent ACS and were divided into control group (patients underwent traditional perioperative management) and ERAS group (patients underwent ERAS perioperative management) based on a random number table.Operational and postoperative data, levels of inflammatory cytokines, stress state evaluation and postoperative complications were observed.The comparison between the two groups was evaluated with an independent sample test.The trend analyses for variables were done using repeated measures ANOVA.The count data were analyzed using the chi-square test or Fisher exact. Eighty-two patients were screened for eligibility, and allocated into the control group (40 patients) and the ERAS group (42 patients). All patients underwent ACS successfully with no death.Comparison of intraoperative status: operation time, volume of intraoperative blood and number of patients receiving blood transfusion were (211.0±12.9) minutes . (207.7±10.7) minutes, (167.5±28.3) ml . (165.0±28.4) ml and 3 cases . 1 case between the control group and the ERAS group, respectively, showing no difference between the two groups (=0.90, 0.29, χ=0.32, all >0.05). Comparison of postoperative status: time of gastric tube removal, time of catheter removal, time of chest tube, time to flatus, time of food intake, duration of postoperative infusion, duration of postoperative hospital stay and numeric rating scale were (3.7±0.5)days . (0.0±0.0)days, (2.3±0.7)days . (1.4±0.5)days, (3.7±0.7)days . (2.3±0.5)days, (75.2±3.8)hours . (46.6±4.2)hours, (75.7±4.7)hours . (21.4±2.1)hours, (10.0±1.0)days . (5.8±0.9)days, (11.4±1.0)days . (7.8±0.6)days, 2.9±0.4 . 1.9±0.6 between the control group and the ERAS group, respectively, with statistically differences (=35.03, 4.36, 8.10, 22.89, 47.78, 14.75, 14.22, 6.13, all <0.05). Stress state evaluation: the levels of IR were (2.7±0.1) .(2.7±0.1), (8.8±0.7) . (5.2±0.3), (11.0±0.5) . (7.3±0.5), (4.9±0.2) . (3.9±0.1), and the levels of C-reaction protein were (14.6±1.3)mg/L .(14.6±1.1) mg/L, (101.2±13.6) mg/L . (89.5±6.9) mg/L, (62.7±8.6) mg/L . (56.4±8.4) mg/L, (46.4±6.7) mg/L . (40.0±5.6) mg/L from pre-operation to postoperative day 1, 3 and 5 between the control group and the ERAS group, respectively, with statistically significant differences in changing trends(=136.61, 4.97, both <0.05). Comparisons of levels of inflammatory cytokines: the levels of IL-6 were (43.1±2.7) ng/L . (43.6±3.6) ng/L, (135.1±6.4) ng/L . (117.4±5.7) ng/L, (145.4±6.7) ng/L . (128.5±5.5) ng/L, (93.3±3.7) ng/L . (88.0±3.9) ng/L, and the levels of TNF-α were (10.4±0.3)mmol/L . (10.4±0.3) mmol/L, (14.4±0.4) mmol/L . (12.6±0.4) mmol/L, (15.6±0.4) mmol/L . (13.8±0.4) mmol/L, (12.3±0.7) mmol/L . (11.4±0.6) mmol/L from pre-operation to postoperative day 1, 3 and 5 between the control group and the ERAS group, respectively, with statistically significant differences in changing trends (=15.15, 21.45, both <0.05). Comparison of postoperative complications: incidence of complications was 30.0%(12/40) in the control group and 11.9%(5/42) in the ERAS group, and the numbers of patients with nausea and vomiting, respiratory complications and cardiovascular complications were 4, 3, 5 cases in the control group and 3, 1, 1 case in the ERAS group, respectively, showing statistically differences in the incidence of complications(χ=4.08, <0.05). All the 82 patients were followed up for 2 to 22 months (median time, 12 months), no patients received reoperation or re-admitted to the hospital duo to complications. ERAS management in the perioperative period of ACS for BCS is beneficial to postoperative recovery of patients, and can relieve postoperative stress state and inflammatory response, reduce the duration of hospital stay, and incidence of postoperative complications.