Department of Neurology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Department of Neurology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
J Neurol Sci. 2017 Sep 15;380:128-131. doi: 10.1016/j.jns.2017.07.024. Epub 2017 Jul 19.
High neutrophil to lymphocyte ratio (NLR) is correlated with the occurrence, morbidity and mortality of cerebrovascular disease as a marker of systemic inflammation. However, its effect on cerebral white matter hyperintensity (WMH) is unclear. We investigated high NLR burden as a surrogate marker of WMH volume in a healthy population. Healthy subjects with voluntary health check-ups between January 2006 and December 2013, including brain MRI and laboratory examination, were collected. WMH volumes were rated quantitatively. A total of 2875 subjects were enrolled, and the mean volume of WMH was 2.63±6.26mL. In multivariate linear regression analysis, NLR [β=0.191, 95% confidence interval (CI)=0.104 to 0.279, P<0.001] remained significant after adjusting for confounders. Age (β=0.049, 95% CI=0.045 to 0.054, P<0.001), hypertension (β=0.191, 95% CI=0.101 to 0.281, P<0.001), diabetes (β=0.153, 95% CI=0.045 to 0.261, P=0.006), and extracranial atherosclerosis (β=0.348, 95% CI=0.007 to 0.688, P=0.045) were also significant independently from NLR. Additionally, the high NLR group (NLR≥1.52) was related to male sex, hypertension, diabetes, current smoking, extracranial atherosclerosis, silent brain infarct, and high WMH volumes. In conclusion, high NLR is associated with larger WMH volumes in a healthy population. Assessment of NLR may be helpful in detecting cerebral WMH burdens in high risk groups.
高中性粒细胞与淋巴细胞比值（NLR）作为全身炎症的标志物与脑血管病的发生、发病率和死亡率相关。然而，其对脑白质高信号（WMH）的影响尚不清楚。我们研究了高 NLR 负担作为健康人群 WMH 体积的替代标志物。收集了 2006 年 1 月至 2013 年 12 月期间自愿健康检查的健康受试者，包括脑 MRI 和实验室检查。WMH 体积被定量评分。共纳入 2875 例受试者，WMH 的平均体积为 2.63±6.26mL。在多变量线性回归分析中，在校正混杂因素后，NLR [β=0.191，95%置信区间（CI）=0.104 至 0.279，P<0.001] 仍有显著意义。年龄（β=0.049，95%CI=0.045 至 0.054，P<0.001）、高血压（β=0.191，95%CI=0.101 至 0.281，P<0.001）、糖尿病（β=0.153，95%CI=0.045 至 0.261，P=0.006）和颅外动脉粥样硬化（β=0.348，95%CI=0.007 至 0.688，P=0.045）也与 NLR 独立相关。此外，高 NLR 组（NLR≥1.52）与男性、高血压、糖尿病、当前吸烟、颅外动脉粥样硬化、无症状性脑梗死和高 WMH 体积相关。总之，高 NLR 与健康人群中较大的 WMH 体积相关。评估 NLR 可能有助于检测高危人群的脑 WMH 负担。
