交流或死亡——一种针对人乳头瘤病毒阳性和阴性癌症干细胞及其与基质细胞衍生因子-1α相互作用的模型

Communicate or Die - A Model for HPV+ and HPV- CSCs and Their Interactions with SDF-1α.

作者信息

Jungbauer Frederic, Aderhold Christoph, Birk Richard, Hoermann Karl, Kramer Benedikt, Kuhlin Beatrice, Thorn Carsten, Umbreit Claudia, Lammert Anne

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.

Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Marburg, University Marburg, Marburg, Germany.

出版信息

Anticancer Res. 2017 Sep;37(9):4827-4836. doi: 10.21873/anticanres.11890.

DOI:10.21873/anticanres.11890

PMID:28870902

Abstract

BACKGROUND/AIM: Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1α (SDF-1α) plays a critical role in the communication between CSCs and their microenvironment. We investigated the influence of SDF-1α on HPV+/HPV- SCC cell lines to find an approach of explanation for the superior prognosis of HPV+ HNSCCs.

MATERIALS AND METHODS

We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1α on proliferation, morphology and migration of HPV+/HPV- SCCs.

RESULTS

HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1α. HPV+ SCCs rested nearly unaffected by SDF-1α.

CONCLUSION

Weakened reaction to SDF-1α in HPV+ SCC could lead to an impaired communication between CSCs and their niche, that would result in an increased exposure of CSCs to the harming influence of e.g. chemotherapeutic agents.

摘要

背景/目的：癌症干细胞（CSCs）被怀疑是头颈部鳞状细胞癌（HNSCC）治疗效果有限的一个原因。基质细胞衍生因子-1α（SDF-1α）在CSCs与其微环境之间的通讯中起关键作用。我们研究了SDF-1α对HPV阳性/阴性鳞状细胞癌细胞系的影响，以寻找一种解释HPV阳性HNSCC预后较好的方法。