Divella Rosa, Daniele Antonella, DE Luca Raffaele, Simone Michele, Naglieri Emanuele, Savino Eufemia, Abbate Ines, Gadaleta Cosmo Damiano, Ranieri Girolamo
Clinical Pathology Laboratory, National Cancer Research Centre, Giovanni Paolo II Tumor institute, Bari, Italy
Clinical Pathology Laboratory, National Cancer Research Centre, Giovanni Paolo II Tumor institute, Bari, Italy.
Anticancer Res. 2017 Sep;37(9):4867-4871. doi: 10.21873/anticanres.11895.
Colorectal cancer is the most common cancer of the gastrointestinal system and has a marked preference to metastasize to distant organs. In this study, we investigated whether levels of circulating serum pro-angiogenic cytokine such as chemokine (C-X-C motif) ligand 1 (melanoma growth-stimulating activity, alpha; CXCL1) and vascular endothelial growth factor (VEGF) have a role in favoring the colonization of metastatic cells at preferential sites and determined their prognostic significance in a cohort of 103 patients with metastatic colorectal cancer. Importantly, we found that the presence of elevated circulating levels of VEGF and CXCL1 are predictive of liver and lung metastasis, respectively. Moreover, the presence of a high serum VEGF level represents a negative prognostic factor for patients with liver metastases, with a worse prognosis than patients with lung metastasis. This suggests an additional role for circulating cytokines as a predictive tool for cancer prognosis and diagnosis, as well as for assessment of tumor sensitivity to anticancer therapy.
结直肠癌是胃肠道最常见的癌症，且明显倾向于转移至远处器官。在本研究中，我们调查了循环血清促血管生成细胞因子水平，如趋化因子（C-X-C基序）配体1（黑素瘤生长刺激活性，α；CXCL1）和血管内皮生长因子（VEGF）是否在促进转移细胞在优先部位的定植中发挥作用，并确定了它们在103例转移性结直肠癌患者队列中的预后意义。重要的是，我们发现循环VEGF和CXCL1水平升高分别预示着肝转移和肺转移。此外，血清VEGF水平高是肝转移患者的不良预后因素，其预后比肺转移患者更差。这表明循环细胞因子在癌症预后和诊断的预测工具方面，以及在评估肿瘤对抗癌治疗的敏感性方面具有额外作用。
