Annede Pierre, Darreon Julien, Benkemouche Ahcene, Valdenaire Simon, Tyran Marguerite, Kaeppelin Bertrand, Macagno Alban, Barrou Julien, Cagetti Leonel Varela, Favrel Veronique, Moureau-Zabotto Laurence, Gonzague Laurence, Fau Pierre, Chargari Cyrus, Tallet Agnes, Salem Naji
Department of Radiotherapy, Institut Paoli Calmettes, Marseille, France
Department of Radiotherapy, Institut Paoli Calmettes, Marseille, France.
Anticancer Res. 2017 Sep;37(9):5133-5139. doi: 10.21873/anticanres.11933.
BACKGROUND/AIM: To assess the clinical impact of high dose rate stereotactic body radiation therapy (SBRT) in patients with lung neoplastic lesions.
From January 2014 to June 2016, a single-center retrospective analysis was performed including all patients treated by either flattening filter free (FFF) beams or flattening filter beams (FF) three-dimensional (3D) SBRT for lung neoplastic lesions.
A total of 99 SBRT were performed on 75 patients. Among these, 29 SBRT were performed using a FFF technique while 70 other SBRT were done using a FF technique. Median follow-up time was 12.9 months. Overall, no difference between the two groups was found except for the mean beam on time which was reduced by 3.3 to 0.9 minutes in the FFF group (p<0.001).
We report a low toxicity rate and a shortened beam on time in patients treated with 3D FFF SBRT for lung neoplastic lesions.
背景/目的：评估高剂量率立体定向体部放射治疗（SBRT）对肺部肿瘤性病变患者的临床影响。
2014年1月至2016年6月，进行了一项单中心回顾性分析，纳入了所有接受无均整器（FFF）射束或有均整器射束（FF）三维（3D）SBRT治疗肺部肿瘤性病变的患者。
共对75例患者进行了99次SBRT。其中，29次SBRT采用FFF技术，另外70次SBRT采用FF技术。中位随访时间为12.9个月。总体而言，两组之间除平均射束开启时间外未发现差异，FFF组的平均射束开启时间从3.3分钟缩短至0.9分钟（p<0.001）。
我们报告了采用3D FFF SBRT治疗肺部肿瘤性病变的患者毒性率低且射束开启时间缩短。
