从事非体力工作的围绝经期和绝经后女性的认知功能与血清皮质醇浓度

Cognitive functions and serum cortisol concentration in perimenopausal and postmenopausal women working non-manually.

作者信息

Raczkiewicz Dorota, Sarecka-Hujar Beata, Owoc Alfred, Bojar Iwona

机构信息

Institute of Statistics and Demography, Warsaw School of Economics, Warsaw, Poland.

School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Poland.

出版信息

Neuro Endocrinol Lett. 2017 Aug;38(4):269-274.

PMID:28871713

Abstract

OBJECTIVES

To asses a possible relationship between serum cortisol concentration and cognitive function in peri- and postmenopausal women engaging in non-manual work.

METHODS

The Montreal Cognitive Assessment (MoCA) was used to screen women for the study and the Computerized Neurocognitive-assessment Software (CNS) Vital Signs to diagnose cognitive functions.

RESULTS

Cognitive functions and serum cortisol concentration did not differ between women in early and late perimenopause and postmenopause. The women in the study obtained lower reaction time compared to other cognitive functions studied. Cognitive functions correlated negatively with age and educational level, but not BMI. Serum cortisol concentration correlated negatively to NCI, motor speed, psychomotor speed and reaction time in postmenopausal women, but positively to complex memory in early perimenopausal women and to processing speed in early and late perimenopasal women.

CONCLUSION

Higher serum cortisol concentration may negatively effect cognitive functions in women post menopause.

摘要

目的

评估从事非体力工作的围绝经期和绝经后女性血清皮质醇浓度与认知功能之间可能存在的关系。

方法

采用蒙特利尔认知评估量表（MoCA）对女性进行研究筛查，并使用计算机神经认知评估软件（CNS）生命体征来诊断认知功能。

结果

围绝经期早期、晚期及绝经后女性的认知功能和血清皮质醇浓度并无差异。与所研究的其他认知功能相比，参与研究的女性反应时间较短。认知功能与年龄和教育水平呈负相关，但与体重指数无关。绝经后女性的血清皮质醇浓度与神经认知指数（NCI）、运动速度、精神运动速度和反应时间呈负相关，但在围绝经期早期女性中与复杂记忆呈正相关，在围绝经期早期和晚期女性中与处理速度呈正相关。