Pinkas Jarosław, Bojar Iwona, Gujski Mariusz, Sarecka-Hujar Beata, Owoc Alfred, Raczkiewicz Dorota
School of Public Health, Center of Postgraduate Medical Education, Warsaw, Poland.
Department of Women's Health, Institute of Rural Health, Lublin, Poland.
Arch Med Sci. 2018 Dec 31;17(1):31-39. doi: 10.5114/aoms.2018.72972. eCollection 2021.
During menopause the level of estrogens is decreased, which may lead to cognitive impairment or dementia. Some forms of genetic polymorphism were found to be related to cognitive functions, including and (II and I) polymorphisms. In the present study we aimed to analyze the impact of interactions between and polymorphisms on cognitive functions in the group of postmenopausal women.
The study group consisted of 266 postmenopausal women aged 50-65 years without symptoms of dementia. A computerized battery of the Central Nervous System Vital Signs (CNS VS) test was used to diagnose cognitive functions. and polymorphisms were genotyped using multiplex PCR and PCR-RFLP methods, respectively. Statistical analysis was performed using two-way analysis of variance in Statistica software.
The best memory, visual memory, processing and psychomotor speeds were found in women carrying the C allele of the II polymorphism (TC + CC genotypes) in the presence of the ε2/ε3 genotype, while a lower outcome was noted in women with ε3/ε3, and the lowest if they had the ε4 allele. In the case of women with TT genotype of the II polymorphism, cognitive functioning did not decrease in women with the ε4 allele. A similar effect on cognitive functions was observed for AG + GG genotypes of the I and polymorphisms. Women who simultaneously carried CC II and GG I genotypes had the lowest cognitive functions.
Interactions of polymorphic variants of and genes influenced cognitive functions in postmenopausal women.
在更年期，雌激素水平下降，这可能导致认知障碍或痴呆。已发现某些形式的基因多态性与认知功能有关，包括[基因名称1]和[基因名称2]（II型和I型）多态性。在本研究中，我们旨在分析[基因名称1]和[基因名称2]多态性之间的相互作用对绝经后女性群体认知功能的影响。
研究组由266名年龄在50 - 65岁、无痴呆症状的绝经后女性组成。使用一套计算机化的中枢神经系统生命体征（CNS VS）测试来诊断认知功能。分别采用多重PCR和PCR-RFLP方法对[基因名称1]和[基因名称2]多态性进行基因分型。使用Statistica软件进行双向方差分析进行统计分析。
在存在[基因名称2] ε2/ε3基因型的情况下，携带[基因名称1] II型多态性C等位基因（TC + CC基因型）的女性具有最佳的记忆、视觉记忆、处理能力和精神运动速度，而ε3/ε3基因型的女性结果较低，如果她们具有ε4等位基因则最低。对于[基因名称1] II型多态性TT基因型的女性，具有ε4等位基因的女性认知功能并未下降。对于[基因名称2] I型多态性的AG + GG基因型，观察到对认知功能有类似影响。同时携带CC II型和GG I型基因型的女性认知功能最低。
[基因名称1]和[基因名称2]基因的多态性变体之间的相互作用影响绝经后女性的认知功能。
