一种荧光团标记的铜配合物：晶体结构、杂环水-高氯酸盐簇及生物学性质
A fluorophore-labelled copper complex: crystal structure, hybrid cyclic water-perchlorate cluster and biological properties.
作者信息
Bhat Satish S, Revankar Vidyanand K, Shivalingegowda Naveen, Lokanath N K
机构信息
Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka 580 003, India.
Institution of Excellence, University of Mysore, Mysuru, Karnataka 570 006, India.
出版信息
Acta Crystallogr C Struct Chem. 2017 Sep 1;73(Pt 9):710-717. doi: 10.1107/S2053229617011639. Epub 2017 Aug 14.
A fluorophore-labelled copper(II) complex, aquabis(dimethylformamide-κO)(perchlorato-κO)[2-(quinolin-2-yl)-1,3-oxazolo[4,5-f][1,10]phenanthroline]copper(II) perchlorate monohydrate, [Cu(ClO)(CHNO)(CHNO)(HO)]ClO·HO, has been synthesized and characterized. A cyclic hydrogen-bonded water-perchlorate anionic cluster, i.e. [(ClO)(HO)], has been identified within the structure. Each cyclic anionic cluster unit is interconnected by hydrogen bonding to the cation. The cations join into an infinite hydrogen-bonded chain running in the [010] direction. Furthermore, interaction of the complex with calf-thymus DNA (CT-DNA) and cellular localization within the cells was explored. Spectroscopic studies indicate that the compound has a good affinity for DNA and stains the nucleus of the cells.
合成并表征了一种荧光团标记的铜（II）配合物，一水合高氯酸双（二甲基甲酰胺-κO）（高氯酸根-κO）[2-（喹啉-2-基）-1,3-恶唑并[4,5-f][1,10]菲咯啉]铜（II），[Cu(ClO)(CHNO)(CHNO)(HO)]ClO·HO。在该结构中鉴定出了一个环状氢键连接的水-高氯酸根阴离子簇，即[(ClO)(HO)]。每个环状阴离子簇单元通过氢键与阳离子相互连接。阳离子连接成沿[010]方向延伸的无限氢键链。此外，还研究了该配合物与小牛胸腺DNA（CT-DNA）的相互作用以及在细胞内的定位。光谱研究表明该化合物对DNA具有良好的亲和力，并能使细胞核染色。
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