Li Hailan, Xiong Zeng, Liu Jinkang, Li Yisha, Zhou Bin
Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Aug 28;42(8):934-939. doi: 10.11817/j.issn.1672-7347.2017.08.010.
To analyze the features of the connective tissue associated interstitial lung disease (CTD-ILD) by high resolution computed tomography (HRCT). Methods: A total of 127 patients with CTD-ILD, who were diagnosed by clinic laboratory examination and pathology in Xiangya Hospital of Central South University form September 2013 to September 2015, were enrolled for this study. Their lung features of HRCT imaging were retrospectively analyzed. Results: The classifications for 127 patients were as follows: 36 cases of rheumatoid arthritis (28.3%), 34 cases of dermatomyositis and polymyositis (26.8%), 31 cases of systemic sclerosis (24.4%), 18 cases of Sjögren syndrome (14.2%), 7 cases of mixed connective tissue disease (5.5%), and 1 cases of systemic lupus erythematosus (0.8%). According to the features of HRCT imaging, the patients were divided as follows: 77 cases (60.6%) of nonspecific interstitial pneumonia (NSIP), 46 cases (36.2%) of usual interstitial pneumonia (UIP), 2 cases (1.6%) of lymphocytic interstitial pneumonia (LIP), 1 case (0.8%) of cryptogenic interstitial pneumonia (COP), and 1 case (0.8%) of acute interstitial pneumonia (AIP). The HRCT findings for 36 cases of rheumatoid arthritis associated interstitial lung disease were UIP (24 cases, 66.7%) and NSIP (12 cases, 33.3%); the HRCT findings for 34 cases of dermatomyositis and polymyositis associated interstitial lung disease were NSIP (32 cases, 94.1%), UIP (1 case, 2.9%) and COP (1 case, 2.9%); the HRCT findings for 31 cases of systemic sclerosis associated interstitial lung disease were NSIP (21 cases, 67.8%), UIP (9 cases, 29%), LIP(1 case, 3.2%); the HRCT findings for 18 cases of Sjögren syndrome associated interstitial lung disease were NSIP (9 cases, 50.0%), UIP (8 cases, 44.4%), LIP (1 case, 5.6%); the HRCT findings for 7 cases of mixed connective tissue disease associated interstitial lung disease were UIP (4 cases, 57.1%), NSIP (3 cases, 42.9%). SLE-ILD was rare, with only 1 case of AIP. Conclusion: Different types of CTD-ILD patients display relatively unique manifestation of HRCT.
通过高分辨率计算机断层扫描（HRCT）分析结缔组织相关性间质性肺病（CTD-ILD）的特征。方法：选取2013年9月至2015年9月在中南大学湘雅医院经临床实验室检查及病理确诊的127例CTD-ILD患者，对其HRCT影像的肺部特征进行回顾性分析。结果：127例患者的分类如下：类风湿关节炎36例（28.3%），皮肌炎和多肌炎34例（26.8%），系统性硬化症31例（24.4%），干燥综合征18例（14.2%），混合性结缔组织病7例（5.5%），系统性红斑狼疮1例（0.8%）。根据HRCT影像特征，患者分为：非特异性间质性肺炎（NSIP）77例（60.6%），普通间质性肺炎（UIP）46例（36.2%），淋巴细胞性间质性肺炎（LIP）2例（1.6%），隐源性机化性肺炎（COP）1例（0.8%），急性间质性肺炎（AIP）1例（0.8%）。36例类风湿关节炎相关性间质性肺病的HRCT表现为UIP（24例，66.7%）和NSIP（12例，33.3%）；34例皮肌炎和多肌炎相关性间质性肺病的HRCT表现为NSIP（32例，94.1%）、UIP（1例，2.9%）和COP（1例，2.9%）；31例系统性硬化症相关性间质性肺病的HRCT表现为NSIP（21例，67.8%）、UIP（9例，29%）、LIP（1例，3.2%）；18例干燥综合征相关性间质性肺病的HRCT表现为NSIP（9例，50.0%）UIP（8例，44.4%）、LIP（1例，5.6%）；7例混合性结缔组织病相关性间质性肺病的HRCT表现为UIP（4例,57.1%）、NSIP（3例，42.9%）。SLE-ILD罕见，仅1例AIP。结论：不同类型的CTD-ILD患者HRCT表现相对独特。
