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人类淋巴细胞亚群的天然细胞毒性反应性。

Natural cytotoxic reactivity of human lymphocyte subpopulations.

作者信息

Potter M R, Moore M

出版信息

Immunology. 1979 May;37(1):187-94.

PMID:288725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457286/
Abstract

The spontaneous cytotoxicity of human peripheral blood lymphocyte preparations from normal donors for K562 target cells was examined. Effector cells were separated into SRBC rosette forming cell (RFC) and non-rosette forming cell (non-RFC) fractions using optimal and suboptimal rosetting procedures. RFC and non-RFC fractions both had high cytotoxic activity irrespective of the rosetting procedure. Owing to the larger size of the RFC fraction, it contained a higher proportion of the total activity in the preparation. Nylon fibre column adherent and non-adherent fractions also both produced cytotoxicity. Nylon fibre non-adherent cells separated by SRBC separation gave a RFC fraction with low activity and a non-RFC fraction with high activity. Separation of nylon fibre adherent cells gave RFC and non-RFC fractions with high cytotoxic activity. Therefore cytotoxic cells did not form a discrete subpopulation and either occur in several lymphocyte subsets or show a variable capacity to form SRBC rosettes and adhere to nylon fibre.

摘要

检测了来自正常供体的人外周血淋巴细胞制剂对K562靶细胞的自发细胞毒性。使用最佳和次优玫瑰花结形成程序将效应细胞分离为SRBC玫瑰花结形成细胞（RFC）和非玫瑰花结形成细胞（非RFC）组分。无论玫瑰花结形成程序如何，RFC和非RFC组分均具有高细胞毒性活性。由于RFC组分的尺寸较大，其在制剂中所含的总活性比例较高。尼龙纤维柱贴壁和非贴壁组分也均产生细胞毒性。通过SRBC分离法分离的尼龙纤维非贴壁细胞产生了低活性的RFC组分和高活性的非RFC组分。尼龙纤维贴壁细胞的分离产生了具有高细胞毒性活性的RFC和非RFC组分。因此，细胞毒性细胞并未形成一个离散的亚群，而是要么存在于几个淋巴细胞亚群中，要么表现出形成SRBC玫瑰花结和粘附于尼龙纤维的可变能力。

相似文献

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Natural cytotoxic reactivity of human lymphocyte subpopulations.人类淋巴细胞亚群的天然细胞毒性反应性。
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本文引用的文献

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Reactivity of lymphocytes from normal persons on cultured tumor cells.正常人淋巴细胞对培养肿瘤细胞的反应性。
Cancer Res. 1973 Nov;33(11):2898-902.
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An improved rosetting assay for detection of human T lymphocytes.一种用于检测人 T 淋巴细胞的改良玫瑰花结试验。
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Cytotoxity of non-T versus T-lymphocytes from melanoma patients and healthy donors on short- and long-term cultured melanoma cells,非T细胞对黑色素瘤患者及健康供体的T淋巴细胞在短期和长期培养的黑色素瘤细胞上的细胞毒性
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Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases.处于各种人类疾病状态下的胸腺来源的玫瑰花结形成细胞：癌症、淋巴瘤、细菌和病毒感染以及其他疾病。
J Clin Invest. 1973 May;52(5):1026-32. doi: 10.1172/JCI107267.
5
Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes.神经氨酸酶处理的绵羊红细胞与人类T淋巴细胞的结合增强。
Blood. 1973 Dec;42(6):939-46.
6
Letter: Cytotoxic lymphocytes from normal donors.信件：来自正常供体的细胞毒性淋巴细胞。
Lancet. 1974 Aug 3;2(7875):296-7.
7
Destruction of human lymphoid tissue-culture cell lines by human peripheral lymphocytes in 51Cr-release cellular cytotoxicity assays.在51Cr释放细胞毒性试验中，人外周血淋巴细胞对人淋巴组织培养细胞系的破坏作用。
J Natl Cancer Inst. 1974 Feb;52(2):345-52. doi: 10.1093/jnci/52.2.345.
8
Performance of a rosette assay between lymphocytes and sheep erythrocytes at elevated temperatures to study patients with cancer and other diseases.在高温条件下进行淋巴细胞与绵羊红细胞的玫瑰花结试验，以研究癌症患者和其他疾病患者。
Clin Immunol Immunopathol. 1976 Jan;5(1):60-6. doi: 10.1016/0090-1229(76)90149-5.
9
Cell-mediate cytotoxicity in vitro of human lymphocytes against a tissue culture melanoma cell line (igr3).人淋巴细胞对一种组织培养黑色素瘤细胞系（igr3）的体外细胞介导细胞毒性。
J Immunol. 1975 Aug;115(2):539-48.
10
PHA stimulation of separated human lymphocyte populations.人淋巴细胞分离群体的PHA刺激
Clin Exp Immunol. 1975 Sep;21(3):456-67.

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