Wu Chun-Chieh, Takahashi Emiko, Asano Naoko, Miyata-Takata Tomoko, Takata Katsuyoshi, Furukawa Katsuya, Elsayed Ahmed Ali, Hu Lei-Ming, Satou Akira, Kohno Kei, Kosugi Hiroshi, Ohashi Kenichi, Kinoshita Tomohiro, Nakamura Shigeo, Kato Seiichi
Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan 807; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan 466-8560.
Department of Surgical Pathology, Aichi Medical University Hospital, Nagakute, Japan 480-1195.
Hum Pathol. 2017 Oct;68:61-68. doi: 10.1016/j.humpath.2017.08.025. Epub 2017 Sep 2.
Among extranodal NK/T-cell lymphoma of nasal type (NKTL), the extranasal variant (ENKTL) is known to have a worse prognosis with advanced clinical stage than the nasal variant of NKTL. However, detailed clinicopathological features of the localized extranasal disease have not been well documented in English literature. Here, we described the clinicopathological profiles of 14 patients with stage I ENKTL, including 7 in the skin, 5 in the gastrointestinal tract, and 2 in the central nervous system, highlighting the distinctiveness of the first. The 7 primary cutaneous (PCNKTL) cases were characterized by an older onset age (median, 76 versus 53 years, P=.012) and a more favorable clinical course (P=.041) compared with 17 patients with stages II-IV ENKTL that showed cutaneous involvement. The skin lesions in the PCNKTL group were distributed in the face or neck (n=4) and limbs (n=3) but not the trunk, which was most frequently affected (60%, P=.017) in the latter group. Furthermore, the stage I cutaneous disease showed a female predominance (male-female, 2:5 versus 7:0; P=.021) and a significantly more favorable survival compared with the noncutaneous stage I ENKTL (P=.037). These results suggest that PCNKTL constitute a distinct subgroup in the nasal-type lymphoma spectrum.
在鼻型结外NK/T细胞淋巴瘤（NKTL）中，已知鼻外型（ENKTL）与鼻型NKTL相比，临床晚期预后更差。然而，局限性鼻外疾病的详细临床病理特征在英文文献中尚未得到充分记录。在此，我们描述了14例I期ENKTL患者的临床病理特征，其中7例发生于皮肤，5例发生于胃肠道，2例发生于中枢神经系统，重点突出了首例的独特性。与17例出现皮肤受累的II-IV期ENKTL患者相比，7例原发性皮肤（PCNKTL）病例的发病年龄较大（中位年龄76岁对53岁，P = 0.012），临床病程更有利（P = 0.041）。PCNKTL组的皮肤病变分布于面部或颈部（n = 4）和四肢（n = 3），而非躯干，后者组躯干受累最为常见（60%，P = 0.017）。此外，I期皮肤疾病以女性为主（男:女，2:5对7:0；P = 0.021），与非皮肤I期ENKTL相比，生存率明显更有利（P = 0.037）。这些结果表明，PCNKTL在鼻型淋巴瘤谱系中构成一个独特的亚组。
