鸡（家鸡）肾刷状缘膜囊泡介导的尿酸盐转运

Carrier-mediated transport of urate by chicken (Gallus domesticus) renal brush-border membrane vesicles.

Kuo S M, Austic R E

Comp Biochem Physiol A Comp Physiol. 1987;87(3):587-95. doi: 10.1016/0300-9629(87)90366-5.

Abstract

Urate is transported by an anion exchange system in chicken renal brush-border membrane vesicles. An outward chloride gradient stimulates an overshoot in urate uptake. 2. The anion exchanger is similar to those described for the kidneys of rats and dogs except that the chicken exchanger has a higher specificity for urate. 3. p-Aminohippurate has only a weak affinity, if any, for the urate exchanger. 4. There were no apparent qualitative differences in urate transport between brush-border membrane vesicles from genetically normouricemic and hyperuricemic chickens.

摘要

尿酸盐通过鸡肾刷状缘膜囊泡中的阴离子交换系统进行转运。外向的氯离子梯度会刺激尿酸盐摄取出现超量。2. 该阴离子交换器与在大鼠和犬肾脏中所描述的那些相似，只是鸡的交换器对尿酸盐具有更高的特异性。3. 对氨基马尿酸对尿酸盐交换器的亲和力（若有的话）很弱。4. 在基因正常尿酸血症鸡和高尿酸血症鸡的刷状缘膜囊泡之间，尿酸盐转运没有明显的质的差异。