Hattesen Andreas Lund, Berg Henrik Karsten, Folkersen Lars, Hvas Anne-Mette
Ugeskr Laeger. 2017 Aug 28;179(35).
This article summarizes the current knowledge of drowning-induced hyperfibrinolytic disseminated intravascular coagulation. Drowning induces respiratory failure with ensuing cardiac arrest, hypoxaemia and ischaemia. A coagulopathy is induced by ischaemia, acidosis and hypothermia, and clinically the patient develops uncontrolled bleeding due to hyperfibrinolysis. A rapid diagnostic approach is required to recognize this hyperfibrinolytic state, since initiation of treatment with antifibrinolytics and fibrinogen concentrate may bring this life-threatening condition to cessation.
本文总结了目前关于溺水诱发的高纤溶状态下弥散性血管内凝血的知识。溺水会引发呼吸衰竭,继而导致心脏骤停、低氧血症和缺血。缺血、酸中毒和低温会诱发凝血病,临床上患者会因高纤溶而出现无法控制的出血。需要一种快速诊断方法来识别这种高纤溶状态,因为使用抗纤溶剂和纤维蛋白原浓缩物进行治疗可能会终止这种危及生命的状况。