Jørgensen Martin Balslev, Videbech Poul, Osler Merete
Ugeskr Laeger. 2017 Sep 4;179(36).
Benzodiazepines (BZ) are widely used for anxiety across psychiatric diagnoses, but for the last decades regulation has been increasingly tight due to problems with tolerance, addiction, withdrawal symptoms and cognitive side effects. Some guidelines claim that BZ only work for a few weeks, and that BZ cause traffic accidents, increased mortality and dementia. In Denmark, the use of BZ has been substantially reduced. In this article it is argued, that not all patients habituate, that most of the epidemiological findings are hampered by confounding, and that there still is a role for long-term use of BZ in the treatment of anxiety.
苯二氮䓬类药物(BZ)广泛用于治疗各类精神疾病中的焦虑症,但在过去几十年里,由于耐受性、成瘾性、戒断症状和认知副作用等问题,相关管控日益严格。一些指导方针称,BZ仅在几周内有效,且会导致交通事故、死亡率上升和痴呆症。在丹麦,BZ的使用量已大幅减少。本文认为,并非所有患者都会上瘾,大多数流行病学研究结果都受到混杂因素的影响,而且BZ在焦虑症的长期治疗中仍有一定作用。