亚抑菌浓度的达巴万星可减弱甲氧西林敏感和耐甲氧西林金黄色葡萄球菌产毒素。
Subinhibitory Dalbavancin Attenuates Exotoxin Production from Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus .
机构信息
Idaho Veterans Research and Education Foundation, Boise, Idaho, USA
Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho, USA.
出版信息
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.01090-17. Print 2017 Nov.
Abstract
This study investigated the effects of subinhibitory doses of the lipoglycopeptide antibiotic dalbavancin on toxin production toxin production levels were compared to those seen with the natural glycopeptide antibiotic vancomycin and with representative beta-lactam and oxazolidinone antibiotics. While neither dalbavancin nor vancomycin adversely affected toxin production, of these glycopeptide antibiotics, only dalbavancin significantly attenuated toxin production at subinhibitory concentrations. These findings support the recent success of dalbavancin for treatment of staphylococcal infections.
摘要
本研究调查了亚抑菌剂量的脂糖肽抗生素达巴万星对毒素产生的影响。将毒素产生水平与天然糖肽抗生素万古霉素以及代表性的β-内酰胺类和恶唑烷酮类抗生素进行了比较。达巴万星和万古霉素均不会对毒素产生不利影响，而这些糖肽抗生素中，只有达巴万星在亚抑菌浓度下显著减弱了毒素的产生。这些发现支持了达巴万星最近在治疗葡萄球菌感染方面的成功。
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