Molecular Epidemiology Group, Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Sci Rep. 2017 Sep 5;7(1):10455. doi: 10.1038/s41598-017-10629-y.
Pregnancy-associated plasma protein-A2 (PAPP-A2), a metalloproteinase purportedly related to pregnancy, foetal growth and development, has recently been described essential for pre-adult growth. Thus, we measured PAPP-A2 in plasma of a non-pregnant population and determined its associations with lifestyle, anthropometric or biochemical factors. In this cross-sectional study of 387 participants (20-70 years) randomly drawn from registration offices near Berlin, Germany, socio-economic and lifestyle factors were assessed by questionnaires, and anthropometric measures and blood samples were taken by trained personnel. Blood was analysed for standard clinical parameters. PAPP-A2 concentration was measured by ELISA. Generalized linear models were used to estimate associations with anthropometric and biochemical factors adjusted for age, sex, and weight. Adjusted mean PAPP-A2 concentration was slightly higher in women (283 pg/mL) than in men (261 pg/mL, p = 0.05) and positively correlated with age (r = 0.17, p = 0.001). PAPP-A2 concentration was inversely associated with body mass index (-2.7 pg/mL per kg/m, p = 0.03) and weight (-1.0 pg/mL per kg, p = 0.01) and positively associated with γ-glutamyl transferase (13.6 pg/mL per SD, p = 0.02), aspartate transaminase (18.5 pg/mL per SD, p = 0.002) and lactate dehydrogenase (14.9 pg/mL per SD, p = 0.02). Our results support that PAPP-A2, beyond its established role in early growth and development is relevant in adult metabolisms.
妊娠相关血浆蛋白 A2（PAPP-A2），一种据称与妊娠、胎儿生长和发育有关的金属蛋白酶，最近被描述为成年前生长所必需。因此，我们测量了非妊娠人群血浆中的 PAPP-A2，并确定了其与生活方式、人体测量或生化因素的关联。在这项德国柏林附近登记处随机抽取的 387 名参与者（20-70 岁）的横断面研究中，通过问卷评估了社会经济和生活方式因素，并由经过培训的人员进行了人体测量测量和血液采样。血液用于分析标准临床参数。通过 ELISA 测量 PAPP-A2 浓度。使用广义线性模型估计与人体测量和生化因素的关联，调整了年龄、性别和体重。调整后的平均 PAPP-A2 浓度在女性（283pg/mL）略高于男性（261pg/mL，p=0.05），与年龄呈正相关（r=0.17，p=0.001）。PAPP-A2 浓度与体重指数（每 kg/m-2.7pg/mL，p=0.03）和体重（每 kg-1.0pg/mL，p=0.01）呈负相关，与 γ-谷氨酰转移酶（每 SD13.6pg/mL，p=0.02）、天冬氨酸转氨酶（每 SD18.5pg/mL，p=0.002）和乳酸脱氢酶（每 SD14.9pg/mL，p=0.02）呈正相关。我们的结果支持 PAPP-A2 除了在早期生长和发育中的既定作用外，在成人代谢中也具有相关性。
