Shekarriz Ramin, Vaziri Mohammad Mehdi
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Int J Hematol Oncol Stem Cell Res. 2017 Apr 1;11(2):108-113.
It has been suggested that inflammatory state due to obesity can lead to alteration in iron metabolism. Women in reproductive age are at higher risk of iron deficiency. In this study, we aimed to evaluate inflammatory status and iron markers in young overweight and obese women. In this study, 120 young and healthy women with a BMI ≥ 25 kg/m2 were enrolled. Biochemical data including iron profile and inflammatory markers were analyzed using mean ± standard deviation or median (interquartile range) and multivariate multiple regression model via MANOVA. Iron deficiency anemia (hemoglobin < 120 g/l) and iron deficiency without anemia (serum ferritin<30.0 mg/l) were detected in 21.67% and 33.33% of participants, respectively. Multivariate modeling showed that BMI was a significant predictor of transferrin saturation (p = 0.037), CRP (p = 0.013), soluble transferrin receptor (p=0.045), and soluble transferrin receptor/ ferritin ratio (0.015). The results of this study supported the positive association between obesity and inflammation and mild changes in iron markers.
有人提出，肥胖引起的炎症状态会导致铁代谢改变。育龄女性缺铁风险更高。在本研究中，我们旨在评估年轻超重和肥胖女性的炎症状态及铁指标。本研究纳入了120名BMI≥25kg/m²的年轻健康女性。使用均值±标准差或中位数（四分位间距）以及通过多变量方差分析的多变量多元回归模型分析了包括铁指标和炎症标志物在内的生化数据。分别在21.67%和33.33%的参与者中检测到缺铁性贫血（血红蛋白<120g/l）和缺铁但无贫血（血清铁蛋白<30.0mg/l）。多变量建模显示，BMI是转铁蛋白饱和度（p = 0.037）、CRP（p = 0.013）、可溶性转铁蛋白受体（p = 0.045）和可溶性转铁蛋白受体/铁蛋白比值（0.015）的显著预测因子。本研究结果支持肥胖与炎症之间的正相关以及铁指标的轻度变化。
