Plewe G, Noelken G, Krause U, Beyer J, del Pozo E
Horm Res. 1987;27(1):7-12. doi: 10.1159/000180771.
The effect of a new long-acting somatostatin analog SMS 201-995 (SMS) on hormonal mechanisms controlling the glucose metabolism was tested in 8 type I diabetics over a 3-day period. In addition to dietary measures and conventional insulin therapy, the patients received a subcutaneous dose of 50 micrograms SMS three times daily for 3 days. Serum growth hormone (GH) was measured at various intervals throughout the investigational period. Glucagon, somatomedin C (SM-C), triiodothyronine, thyroxine, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) were also determined before and at the end of the therapy with SMS. Basal GH and plasma SM-C had decreased significantly (p less than 0.05 and p less than 0.01, respectively) by the 3rd day. In all cases the insulin requirements could be reduced (mean 28%) without deterioration of the metabolic control. Moreover, blood glucose profiles showed a tendency to lower postprandial peaks after SMS treatment. Glucagon, triiodothyronine, thyroxine, LH, FSH and PRL showed no significant changes. No side effects or alterations in laboratory chemistries were recorded. Dampening of glucose oscillations and counterregulatory mechanisms, and reduction of insulin dosage by SMS may enable a better control of unstable diabetes. Its slow plasma clearance and long action compared to the native peptide will warrant the use of this analog as a additive to standard diabetes therapy in more prolonged trials.
在8名I型糖尿病患者中，对一种新型长效生长抑素类似物SMS 201-995（SMS）在控制葡萄糖代谢的激素机制方面的作用进行了为期3天的测试。除饮食措施和常规胰岛素治疗外，患者连续3天每天皮下注射50微克SMS，共3次。在整个研究期间的不同时间间隔测量血清生长激素（GH）。在使用SMS治疗前和治疗结束时还测定了胰高血糖素、生长调节素C（SM-C）、三碘甲状腺原氨酸、甲状腺素、促黄体生成素（LH）、促卵泡激素（FSH）和催乳素（PRL）。到第3天，基础GH和血浆SM-C显著下降（分别为p<0.05和p<0.01）。在所有病例中，胰岛素需求量均可降低（平均28%），而代谢控制并未恶化。此外，血糖曲线显示，SMS治疗后餐后峰值有降低趋势。胰高血糖素、三碘甲状腺原氨酸、甲状腺素、LH、FSH和PRL无显著变化。未记录到副作用或实验室检查结果的改变。SMS对葡萄糖振荡和反调节机制的抑制作用以及胰岛素剂量的减少可能有助于更好地控制不稳定型糖尿病。与天然肽相比，其血浆清除缓慢且作用持久，这将保证在更长时间的试验中使用这种类似物作为标准糖尿病治疗的添加剂。
