Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.
Adv Exp Med Biol. 2017;1011:1-85. doi: 10.1007/978-94-024-1170-6_1.
The immune system is a central determinant of organismal health. Functional immune responses require quiescent immune cells to rapidly grow, proliferate, and acquire effector functions when they sense infectious agents or other insults. Specialized metabolic programs are critical regulators of immune responses, and alterations in immune metabolism can cause immunological disorders. There has thus been growing interest in understanding how metabolic processes control immune cell functions under normal and pathophysiological conditions. In this chapter, we summarize how metabolic programs are tuned and what the physiological consequences of metabolic reprogramming are as they relate to immune cell homeostasis, differentiation, and function.
免疫系统是决定生物体健康的核心因素。功能性免疫反应需要静息免疫细胞在感知到感染因子或其他刺激时迅速生长、增殖并获得效应功能。专门的代谢程序是免疫反应的关键调节剂，免疫代谢的改变可导致免疫紊乱。因此，人们越来越感兴趣的是了解代谢过程如何在正常和病理生理条件下控制免疫细胞的功能。在本章中，我们总结了代谢程序是如何调整的，以及代谢重编程与免疫细胞稳态、分化和功能相关的生理后果是什么。
