Department of Medicine (Rheumatology), Yale University School of Medicine, New Haven, CT 06520, USA.
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Science. 2019 Jan 11;363(6423). doi: 10.1126/science.aar3932.
Metabolism is at the core of all biological functions. Anabolic metabolism uses building blocks that are either derived from nutrients or synthesized de novo to produce the biological infrastructure, whereas catabolic metabolism generates energy to fuel all biological processes. Distinct metabolic programs are required to support different biological functions. Thus, recent studies have revealed how signals regulating cell quiescence, proliferation, and differentiation also induce the appropriate metabolic programs. In particular, a wealth of new studies in the field of immunometabolism has unveiled many examples of the connection among metabolism, cell fate decisions, and organismal physiology. We discuss these findings under a unifying framework derived from the evolutionary and ecological principles of life history theory.
新陈代谢是所有生物功能的核心。合成代谢利用来源于营养物质或从头合成的构建块来产生生物基础设施，而分解代谢则产生能量来为所有生物过程提供燃料。支持不同生物功能需要不同的代谢程序。因此，最近的研究揭示了调节细胞静止、增殖和分化的信号如何诱导适当的代谢程序。特别是，免疫代谢领域的大量新研究揭示了代谢、细胞命运决定和机体生理学之间联系的许多例子。我们根据生命历史理论的进化和生态原则得出的统一框架来讨论这些发现。
