FKBP5甲基化作为健康人类受试者皮质醇状态和短暂皮质醇暴露的一种可能标志物。
FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects.
作者信息
Winkler Britta K, Lehnert Hendrik, Oster Henrik, Kirchner Henriette, Harbeck Birgit
机构信息
Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
出版信息
Epigenomics. 2017 Oct;9(10):1279-1286. doi: 10.2217/epi-2017-0057. Epub 2017 Sep 6.
UNLABELLED
Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects.
AIM
To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short- and long-term marker for cortisol exposure in humans.
MATERIALS & METHODS: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined.
RESULTS
A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses.
CONCLUSION
Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.
未标注
目前用于肾上腺功能不全的糖皮质激素替代方案无法模拟生理性皮质醇分泌，从而引发严重副作用。
目的
通过实验评估FKBP5基因内CpG甲基化作为人类皮质醇暴露可能的短期和长期标志物的影响。
材料与方法
进行促肾上腺皮质激素（ACTH）刺激试验，并测定白细胞中FKBP5基因的甲基化状态。
结果
观察到甲基化基础水平与血清皮质醇之间呈负相关。24小时后FKBP5甲基化的个体变化与皮质醇反应相关。
结论
考虑到之前对小鼠白细胞进行的研究，FKBP5甲基化可能也适用于人类，作为一种长期生物标志物，而非急性糖皮质激素暴露的标志物。
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