Miura M, Takayama K, Okada J
J Auton Nerv Syst. 1987 Jun;19(3):179-88. doi: 10.1016/0165-1838(87)90064-6.
By using a multibarrelled microelectrode, the possibility that putative transmitters may influence on the field potential evoked in the solitary tract nucleus by electrical stimulation of the carotid sinus nerve (the NTS response) was examined electrophysiologically in the cat. After iontophoretic application of a selective antagonist to the putative transmitter, it was determined whether or not the NTS response was influenced. Both substance P antagonist and naloxone altered the NTS response recorded in the depressor and apneic (or hypopneic) response zone as well as in the pressor and apneustic (or inspiratory) response zone throughout the rostral, intermediate and commissure regions, suggesting that substance P and opioid peptide may play the role of excitatory transmitters. Under the polarizing cathodal current which may activate inhibitory inputs to the site of the NTS response, bicuculline and prazosin strongly enhanced the NTS response recorded in the pressor and apneustic zone, while naloxone weakly enhanced the NTS response recorded in the depressor and apneic zone. These results suggest that gamma-aminobutyric acid, alpha-adrenergic agonist and opioid peptide may have an inhibitory influence on the NTS response.
通过使用多管微电极，采用电生理学方法在猫身上研究了假定递质是否可能影响由颈动脉窦神经电刺激（NTS反应）诱发的孤束核场电位。在向假定递质离子导入选择性拮抗剂后，确定NTS反应是否受到影响。P物质拮抗剂和纳洛酮均改变了在延髓头端、中间和连合区域的降压和呼吸暂停（或呼吸减弱）反应区以及升压和长吸（或吸气）反应区记录到的NTS反应，提示P物质和阿片肽可能发挥兴奋性递质的作用。在可能激活NTS反应部位抑制性输入的极化阴极电流作用下，荷包牡丹碱和哌唑嗪强烈增强了在升压和长吸区记录到的NTS反应，而纳洛酮则微弱增强了在降压和呼吸暂停区记录到的NTS反应。这些结果提示，γ-氨基丁酸、α-肾上腺素能激动剂和阿片肽可能对NTS反应具有抑制作用。
