Ujka Kristian, Bruno Rosa Maria, Bastiani Luca, Bernardi Eva, Sdringola Paolo, Dikic Nenad, Basyal Bikash, Bhandari Sanjeeb Sundarshan, Basnyat Buddha, Cogo Annalisa, Pratali Lorenza
1 Institute of Clinical Physiology-CNR , Pisa, Italy .
2 Department of Clinical and Experimental Medicine, University of Pisa , Pisa, Italy .
High Alt Med Biol. 2017 Sep;18(3):249-257. doi: 10.1089/ham.2016.0104. Epub 2017 Sep 6.
Ujka, Kristian, Rosa Maria Bruno, Luca Bastiani, Eva Bernardi, Paolo Sdringola, Nenad Dikic, Bikash Basyal, Sanjeeb Sundarshan Bhandari, Buddha Basnyat, Annalisa Cogo, and Lorenza Pratali. Relationship between occupational physical activity and subclinical vascular damage in moderate-altitude dwellers. High Alt Med Biol. 18:249-257, 2017.
Occupational physical activity (OPA) has been associated with increased cardiovascular (CV) events. The aim of this study was to investigate the association between OPA and markers of subclinical vascular damage among a moderate-altitude population living in the rural village of Chaurikharka (Nepal; 2600 m sea level).
Seventy-two individuals (age 42 ± 15 years, ranges 15-85 years, 23 men) were enrolled. Physical activity (PA) was evaluated using the International Physical Activity Questionnaire (IPAQ). Carotid-femoral pulse wave velocity (PWV), carotid ultrasound assessment, and flow-mediated dilation (FMD) were performed.
OPA was 9860 ± 5385 Metabolic Equivalent of Task (MET)-minutes/week, representing 77% of total energy expenditure, with 97% of the population performing high-intensity PA. In the univariate analysis, OPA was significantly associated with PWV (β = 0.474, p = 0.001) and carotid stiffness (CS) (β = 0.29, p = 0.019). In the multivariate analysis, including age, sex, oxygen saturation, mean blood pressure, low-density lipoprotein (LDL), and OPA, OPA remained an independent predictor of PWV (β = 0.403, p = 0.001) but not of CS (β = 0.028, p = 0.8). OPA remained an independent predictor of PWV independently from the Framingham risk score (FRS).
High-intensity OPA shows a positive, independent association with aortic stiffness in Himalayan moderate-altitude dwellers. This study suggests how vigorous OPA performed in moderate altitude may be a CV risk factor.
乌伊卡，克里斯蒂安，罗莎·玛丽亚·布鲁诺，卢卡·巴斯蒂亚尼，伊娃·贝尔纳迪，保罗·斯德林戈拉，纳纳德·迪基奇，比卡什·巴萨亚尔，桑吉布·桑达尔尚·班达里，布达·巴斯尼亚特，安娜丽莎·科戈，洛伦扎·普拉塔利。中等海拔居民职业体力活动与亚临床血管损伤的关系。《高海拔医学与生物学》。2017年第18卷：249 - 257页。
职业体力活动（OPA）与心血管（CV）事件增加有关。本研究旨在调查尼泊尔乔里卡尔卡乡村（海拔2600米海平面）中等海拔人群中OPA与亚临床血管损伤标志物之间的关联。
招募了72名个体（年龄42±15岁，范围15 - 85岁，23名男性）。使用国际体力活动问卷（IPAQ）评估体力活动（PA）。进行了颈股脉搏波速度（PWV）、颈动脉超声评估和血流介导的血管舒张（FMD）检查。
OPA为9860±5385代谢当量任务（MET）-分钟/周，占总能量消耗的77%，97%的人群进行高强度PA。在单变量分析中，OPA与PWV（β = 0.474，p = 0.001）和颈动脉僵硬度（CS）（β = 0.29，p = 0.019）显著相关。在多变量分析中，纳入年龄、性别、血氧饱和度、平均血压、低密度脂蛋白（LDL）和OPA后，OPA仍然是PWV的独立预测因子（β = 0.403，p = 0.001），但不是CS的独立预测因子（β = 0.028，p = 0.8）。独立于弗雷明汉风险评分（FRS），OPA仍然是PWV的独立预测因子。
在喜马拉雅中等海拔居民中，高强度OPA与主动脉僵硬度呈正相关且具有独立性。本研究表明在中等海拔进行的剧烈OPA可能是一种心血管危险因素。
