反应抑制和基因-环境相互作用在青少年外化问题发展途径中的作用。
Roles of Response Inhibition and Gene-Environment Interplay in Pathways to Adolescents' Externalizing Problems.
机构信息
Arizona State University.
University of Missouri.
出版信息
J Res Adolesc. 2017 Jun;27(2):258-277. doi: 10.1111/jora.12270. Epub 2016 Jun 10.
Abstract
This study used two waves of data to investigate pathways through which adolescents' response inhibition related to later externalizing problems. A polygenic risk score indexed genetic risk for poor response inhibition. Adolescents' performance on a response inhibition task mediated the relation between adolescents' polygenic risk scores and mother's inconsistent parenting (i.e., evocative rGE), even after controlling for mothers' genetic risk (i.e., passive rGE). Mothers' inconsistent parenting subsequently prospectively predicted adolescents' externalizing problems. Adolescents' response inhibition also prospectively predicted later externalizing behaviors. These findings were subgroup-specific, with greater risk for non-Hispanic Caucasian boys with substance-disordered parents. Results suggest that poor response inhibition may increase risk for adolescents' externalizing problems both directly and by evoking certain environmental conditions.
摘要
本研究使用两波数据来探究青少年反应抑制与后期外化问题之间的关联途径。多基因风险评分指标反映了对反应抑制不良的遗传风险。青少年在反应抑制任务上的表现中介了青少年多基因风险评分与母亲不一致教养（即诱发 rGE）之间的关系，即使在控制了母亲的遗传风险（即被动 rGE）之后也是如此。母亲的不一致教养随后前瞻性地预测了青少年的外化问题。青少年的反应抑制也前瞻性地预测了后来的外化行为。这些发现具有亚组特异性，对于有物质障碍父母的非西班牙裔白种男孩风险更大。研究结果表明，反应抑制不良可能会直接增加青少年外化问题的风险，也可能通过引发某些环境条件来增加风险。
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