Delfin Carl, Ruzich Emily, Wallinius Märta, Björnsdotter Malin, Andiné Peter
Centre for Ethics, Law and Mental Health, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Research Department, Regional Forensic Psychiatric Clinic, Växjö, Sweden.
Front Psychiatry. 2020 Dec 11;11:577491. doi: 10.3389/fpsyt.2020.577491. eCollection 2020.
Trait disinhibition may function as a dispositional liability toward maladaptive behaviors relevant in the treatment of mentally disordered offenders (MDOs). Reduced amplitude and prolonged latency of the NoGo N2 and P3 event-related potentials have emerged as promising candidates for transdiagnostic, biobehavioral markers of trait disinhibition, yet no study has specifically investigated these two components in violent, inpatient MDOs. Here, we examined self-reported trait disinhibition, experimentally assessed response inhibition, and NoGo N2 and P3 amplitude and latency in male, violent MDOs ( = 27) and healthy controls ( = 20). MDOs had a higher degree of trait disinhibition, reduced NoGo P3 amplitude, and delayed NoGo P3 latency compared to controls. The reduced NoGo P3 amplitude and delayed NoGo P3 latency in MDOs may stem from deficits during monitoring or evaluation of behavior. NoGo P3 latency was associated with increased trait disinhibition in the whole sample, suggesting that trait disinhibition may be associated with reduced neural efficiency during later stages of outcome monitoring or evaluation. Findings for NoGo N2 amplitude and latency were small and non-robust. With several limitations in mind, this is the first study to demonstrate attenuated NoGo P3 amplitude and delayed NoGo P3 latency in violent, inpatient MDOs compared to healthy controls.
特质去抑制可能作为一种倾向性因素，导致与精神障碍罪犯（MDOs）治疗相关的适应不良行为。抑制信号（NoGo）N2和P3事件相关电位的波幅降低和潜伏期延长，已成为特质去抑制的跨诊断生物行为标志物的有前景的候选指标，但尚无研究专门针对暴力住院MDOs中的这两个成分进行调查。在此，我们检查了男性暴力MDOs（n = 27）和健康对照者（n = 20）的自我报告特质去抑制、实验评估的反应抑制，以及抑制信号N2和P3的波幅和潜伏期。与对照组相比，MDOs具有更高程度的特质去抑制、降低的抑制信号P3波幅和延迟的抑制信号P3潜伏期。MDOs中抑制信号P3波幅降低和潜伏期延迟可能源于行为监测或评估过程中的缺陷。在整个样本中，抑制信号P3潜伏期与特质去抑制增加相关，这表明特质去抑制可能与结果监测或评估后期阶段的神经效率降低有关。抑制信号N2波幅和潜伏期的研究结果较小且不稳定。考虑到若干局限性，这是第一项证明与健康对照者相比，暴力住院MDOs中抑制信号P3波幅减弱和潜伏期延迟的研究。
