Lewin ToxConsulting, Hannover, Germany.
Pfizer Global Research & Development, Groton, Connecticut.
Birth Defects Res. 2017 Nov 15;109(19):1519-1539. doi: 10.1002/bdr2.1089. Epub 2017 Sep 6.
The purpose of this review is to give an outline of respiratory tract morphological and functional development with an emphasis on perinatal and postnatal maturational processes. In view of the rising need for qualitative and quantitative data for the development of pediatric pharmaceuticals, a comparison of the human situation to experimental animal models is made, and functional data as well as suitable models for human airway diseases and functional testing are presented. Birth Defects Research 109:1519-1539, 2017. © 2017 Wiley Periodicals, Inc.
本综述旨在概述呼吸道的形态和功能发育，重点介绍围产期和出生后成熟过程。鉴于儿科药物开发对定性和定量数据的需求不断增加，本文将人类情况与实验动物模型进行了比较，并介绍了功能数据以及用于人类气道疾病和功能测试的合适模型。出生缺陷研究 109:1519-1539, 2017。© 2017 Wiley Periodicals, Inc.
