Nkohkwo Asa'ah, Agbor Gabriel, Asongalem Emmanuel, Tagny Claude, Asonganyi Tazoacha
N-S TechnoMed, London, United Kingdom.
Department of Biochemistry, Institute of Medical Research and Medicinal Plants Studies, Yaoundé, Cameroon.
Afr J Lab Med. 2016 Jun 9;5(1):363. doi: 10.4102/ajlm.v5i1.363. eCollection 2016.
Despite vast improvements in transfusion services in sub-Saharan Africa over the last decade, there remain serious concerns on the safety and adequacy of the blood supply across the region.
This review paper ascertains the role of pathogen reduction technology (PRT) in improving blood safety and supply adequacy in the region.
The state of blood safety in sub-Saharan Africa was reviewed. Meetings, seminars and correspondence were undertaken with key clinicians, scientists and professional bodies in the region, including the World Health Organization's Regional Office for Africa, to examine the suitability of PRT for improving the safety of whole blood transfusion, a prevalent transfusion format in the region.
Existing literature suggests that combining PRT with current blood safety measures (such as serology) would improve the safety and adequacy of the blood supply for transfusions in sub-Saharan Africa. This was echoed by the findings of the stakeholder meetings.
Following a detailed appraisal of two leading PRT systems, the Mirasol PRT System and the Cerus S-303 System, we suggest that companies conduct comprehensive toxicological evaluation of the agents used for PRT and publish this in the scientific literature. We also recommend that the safety and efficacy of these technologies should be established in a randomised clinical trial conducted in sub-Saharan Africa.
尽管在过去十年里撒哈拉以南非洲地区的输血服务有了巨大改善，但该地区血液供应的安全性和充足性仍令人严重担忧。
这篇综述文章确定病原体灭活技术（PRT）在改善该地区血液安全和供应充足性方面的作用。
对撒哈拉以南非洲地区的血液安全状况进行了综述。与该地区的关键临床医生、科学家和专业机构（包括世界卫生组织非洲区域办事处）举行了会议、研讨会并进行了通信，以研究PRT对于改善全血输血安全性的适用性，全血输血是该地区一种普遍的输血形式。
现有文献表明，将PRT与当前的血液安全措施（如血清学检测）相结合，将提高撒哈拉以南非洲地区输血用血的安全性和充足性。利益相关者会议的结果也证实了这一点。
在对两种领先的PRT系统（Mirasol PRT系统和Cerus S - 303系统）进行详细评估后，我们建议企业对用于PRT的试剂进行全面的毒理学评估，并将结果发表在科学文献中。我们还建议应在撒哈拉以南非洲地区进行的随机临床试验中确定这些技术的安全性和有效性。
