Environmental Epidemiology Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute (NCI), Rockville, Maryland.
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland.
Cancer Med. 2017 Oct;6(10):2419-2423. doi: 10.1002/cam4.1153. Epub 2017 Sep 6.
Heavy alcohol drinking is associated with increased breast cancer risk, but associations with low-to-moderate alcohol consumption are less clear and the biological mechanisms are not well defined. The objective of this study was to evaluate the effects of 8 weeks of low (15 g/d) and moderate (30 g/d) alcohol ingestion on concentrations of 15 urinary estrogen metabolites (EMs) in postmenopausal women (n = 51) in a controlled feeding study with a randomized crossover design. Compared to no alcohol, 15 g/day for 8 weeks had no effect on urinary EMs. However, compared to no alcohol, 30 g/day for 8 weeks decreased urinary 2-hydroestrone (2-OHE1) by 3.3% (P = 0.055) and increased 16-epiestriol (16-EpiE3) by 26.6% (P = 0.037). Trends for reduced urinary 2-OHE1 (P = 0.045), reduced ratio of 2-OH:16OH pathways (P = 0.008), and increased 16-EpiE3 (P = 0.035) were observed as alcohol ingestion increased from 0 g to 15 g to 30 g/d. Moderate alcohol consumption for 8 weeks had modest effects on urinary concentrations of 2-OHE1 and 16-EpiE3 among postmenopausal women in a carefully controlled feeding study.
大量饮酒与乳腺癌风险增加有关，但低至中度饮酒与乳腺癌的关系尚不清楚，其生物学机制也尚未明确。本研究的目的是在一项精心控制的喂养研究中，评估 8 周内低（15 克/天）和中度（30 克/天）饮酒对 51 名绝经后妇女尿液中 15 种雌激素代谢物（EMs）浓度的影响，采用随机交叉设计。与不饮酒相比，8 周内每天饮酒 15 克对尿液 EMs 没有影响。然而，与不饮酒相比，8 周内每天饮酒 30 克使尿液中 2-羟雌酮（2-OHE1）降低 3.3%（P=0.055），16-表雌三醇（16-EpiE3）增加 26.6%（P=0.037）。随着饮酒量从 0 克增加到 15 克再增加到 30 克/天，尿液 2-OHE1 减少（P=0.045）、2-OH:16OH 途径比值降低（P=0.008）和 16-EpiE3 增加（P=0.035）的趋势均有观察到。在一项精心控制的喂养研究中，绝经后妇女 8 周中等量饮酒对尿液 2-OHE1 和 16-EpiE3 浓度有适度影响。
