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1 例T淋巴母细胞淋巴瘤白血病累及皮肤的病例

A Case of Cutaneous Involvement in T Lymphoblastic Lymphoma Leukemia.

作者信息

Zhang Ling, Zeng Yunxin, Cheng Na, Liu Xiaoyun, Li Xiaoqing, Long Bing, Lin Dongjun

出版信息

Clin Lab. 2017 Sep 1;63(9):1497-1500. doi: 10.7754/Clin.Lab.2017.170222.

Abstract

BACKGROUND

Cutaneous involvement is more prevalent in B lymphoblastic lymphoma (B-LBL) than T lymphoblastic lymphoma (T-LBL). The authors describe a rare case of cutaneous involvement in a 25-year-old woman with T lymphoblastic lymphoma leukemia.

METHODS

Hematologic investigation, bone marrow aspirate and biopsy, cytogenetic analysis and cutaneous lesion biopsy were performed.

RESULTS

The patient achieved complete remission after induction therapy with the regimen of CHOEP + P, then received another CHOEP + P regimen. Unfortunately, the patient refused further treatment and was lost to follow-up.

CONCLUSIONS

Skin biopsy, immunohistochemistry of the skin lesions, bone marrow aspirate, and biopsy are important to confirm a diagnosis of T-LBL. Cutaneous involvement in T-LBL as a prognostic factor needs further studies.

摘要

背景

皮肤受累在B淋巴母细胞淋巴瘤(B-LBL)中比T淋巴母细胞淋巴瘤(T-LBL)更常见。作者描述了一例25岁患T淋巴母细胞淋巴瘤白血病的女性出现皮肤受累的罕见病例。

方法

进行了血液学检查、骨髓穿刺和活检、细胞遗传学分析以及皮肤病变活检。

结果

患者接受CHOEP + P方案诱导治疗后达到完全缓解,随后又接受了另一疗程的CHOEP + P方案。不幸的是,患者拒绝进一步治疗并失访。

结论

皮肤活检、皮肤病变的免疫组织化学检查、骨髓穿刺和活检对于确诊T-LBL很重要。T-LBL中的皮肤受累作为一个预后因素需要进一步研究。

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