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环糊精催化的有机合成：反应、机制与应用。

Cyclodextrin-Catalyzed Organic Synthesis: Reactions, Mechanisms, and Applications.

机构信息

School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.

Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Yinchuan 750004, China.

出版信息

Molecules. 2017 Sep 7;22(9):1475. doi: 10.3390/molecules22091475.

DOI:10.3390/molecules22091475
PMID:28880241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6151768/
Abstract

Cyclodextrins are well-known macrocyclic oligosaccharides that consist of α-(1,4) linked glucose units and have been widely used as artificial enzymes, chiral separators, chemical sensors, and drug excipients, owing to their hydrophobic and chiral interiors. Due to their remarkable inclusion capabilities with small organic molecules, more recent interests focus on organic reactions catalyzed by cyclodextrins. This contribution outlines the current progress in cyclodextrin-catalyzed organic reactions. Particular emphases are given to the organic reaction mechanisms and their applications. In the end, the future directions of research in this field are proposed.

摘要

环糊精是众所周知的大环寡糖，由α-（1,4）连接的葡萄糖单元组成，由于其具有疏水性和手性内腔，已被广泛用作人工酶、手性分离剂、化学传感器和药物赋形剂。由于其对小分子有机分子的显著包合能力，最近的研究兴趣集中在环糊精催化的有机反应上。本贡献概述了环糊精催化的有机反应的最新进展。特别强调了有机反应机制及其应用。最后，提出了该领域未来的研究方向。

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